• 中国科学论文统计源期刊
  • 中国科技核心期刊
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临床输血与检验

临床输血与检验 ›› 2017, Vol. 19 ›› Issue (1): 63-66.DOI: 10.3969/j.issn.1671-2587.2017.01.018

• 临床检验 • 上一篇    下一篇

IL-22、IL-27、VEGF、TF及TFPI对良恶性浆膜腔积液的鉴别价值*

赖馨, 李小峰, 陈丽芳, 胡琴, 万彦彬, 林建华   

  1. 518172 广东省深圳市龙岗区人民医院检验科（赖馨 ,李小峰,陈丽芳,胡琴,万彦彬）;
    中山大学附属肿瘤医院检验科（林建华）
  • 收稿日期:2016-08-27 出版日期:2017-02-20 发布日期:2017-03-02
  • 作者简介:赖馨（1987-）,女,江西吉安人,主管检验师,学士,主要从事临床检验基础工作,（E-mail）mmyoo35@163.com。
  • 基金资助:
    *本课题受广东省深圳市龙岗区科技发展资金医疗卫生项目（No; YLWS20150513173417559）资助

The Diagnostic Value of IL-22,IL-27,VEGF,TF and TFPI in Benign and Malignant Pleural Effusion

LAI Xin, LI Xiao-feng, CHEN Li-fang, et al   

  1. Department of Clinical Laboratory,Longgang District People′s Hospital,Shenzhen 518172
  • Received:2016-08-27 Online:2017-02-20 Published:2017-03-02

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摘要： 目的 评估浆膜腔积液中白介素22（interleukin-22,IL-22）、IL-27、血管内皮生长因子（vascular endothelial growth factor,VEGF）、组织因子（tissue factor,TF）和组织因子途径抑制物（tissue factor pathway inhibitor,TFPI）水平在鉴别良恶性浆膜腔积液中的价值。方法 应用酶联免疫吸附测定（ELISA）法检测41例病理学和影像学检测确诊为恶性浆膜腔积液患者、41例良性浆膜腔积液患者的浆膜腔积液中IL-22、IL-27、VEGF、TF和TFPI水平,并加以分析。结果 恶性浆膜腔积液患者的浆膜腔积液中IL-22、IL-27、VEGF、TF和TFPI水平明显高于良性浆膜腔积液患者,差异均具有统计学意义（P<0.05）。ROC分析表明,恶性浆膜腔积液中IL-22、IL-27、VEGF、TF和TFPI的ROC曲线下面积分别为0.638、0.750、0.687、0.568和0.657。而联合这5个指标建立的预测诊断模型,ROC曲线下面积为0.793。结论 浆膜腔积液中IL-22、IL-27、VEGF、TF和TFPI水平对鉴别良恶性浆膜腔积液有重要参考价值。

关键词: 白介素22, 白介素27, 血管内皮生长因子, 组织因子, 组织因子途径抑制物, 浆膜腔积液, 受试者工作特征曲线

Abstract: Objective To investigate the diagnostic value of IL-22,IL-27,VEGF,TF and TFPI inhibitor value in the benign and malignant pleural effusions. Method Selected ninety pleural patients were subdivided into two groups according to the Results of pathology and iconography diagnosis,ie the benign pleural effusions （benign） group with 43 cases and malignant pleural effusions （malignant） group with 47 cases. To test the diagnostic ability of several indicators used alone and in combination,the concentrations of IL-22,IL-27,VEFG,TF and TFPI were determined by ELISA Method,and the concentrations of these five biomarkers in pleural effusion were compared,then receiver operating curve （ROC） analysis was performed. Results A significant difference of IL-22,IL-27,VEGF,TF and TFPI levels were observed in patients with malignant and benign pleural effusion （P<0.05）. Receiver operating curve analysis indicated that several indicators used alone showed a less potent diagnostic ability of benign and malignant pleural effusion,the area under the ROC curve of less than 0.8; while these biomarkers used in combination showed an obvious improvement in sensitivity,specificity and accuracy. Conclusion The combination of several biomarkers can provide a reference for the differential diagnosis of benign and malignant pleural effusion. Because of the high accuracy,efficiency and simplicity,this Method is worthy promotion.

Key words: IL-22, IL-27, VEGF, TF, TFPI, Serous cavity effusion, Ros curve

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