输血相关急性肺损伤的发病机制及预防策略

doi:10.3969/j.issn.1671-2587.2017.02.034

临床输血与检验 ›› 2017, Vol. 19 ›› Issue (2): 205-209.DOI: 10.3969/j.issn.1671-2587.2017.02.034

• 综述 • 上一篇

输血相关急性肺损伤的发病机制及预防策略

邱丽

300456 天津市滨海新区塘沽中心血站

收稿日期:2016-10-24 出版日期:2017-04-20 发布日期:2017-04-24
作者简介:邱丽（1982-）,女,回族,天津人,主管技师,学士,主要从事输血免疫学工作,（Tel）13702129325（E-mail）qiuli1982@126.com。

The Pathogenesis and Prevention Strategies of Transfusion Related Acute Lung Injury

QIU Li

Binhai Tanggu Blood Station,Tianjin 300456

Received:2016-10-24 Online:2017-04-20 Published:2017-04-24

摘要/Abstract

摘要： 输血相关急性肺损伤（TRALI）是指输入血制品6 h内发生的急性肺损伤,是输血导致患者死亡的主要原因之一。TRALI的发病机制有抗体介导和非抗体介导两种,同时较为认可的“二次打击学说”和阈值模型也得到许多动物模型试验的支持。在TRALI的发病机制中中性粒细胞的激活扮演着重要作用。因此,临床制定严格的输血策略是预防TRALI的最有效方法,供血机构排除高风险献血者（如有多次妊娠史的女性献血者）也会有效降低TRALI的发生发展。同时,临床和供血机构仍在探讨“量身输血”、血浆汇集等策略对降低TRALI发生的可行性。

关键词: 输血相关急性肺损伤, 发病机制, 预防策略

Abstract: Transfusion related acute lung injury（TRALI）,which is defined as the onset of acute lung injury within 6h of transfusion,is the most common cause of transfusion related death worldwide.The two most prevalent pathogenesis of TRALI are antibody mediated and non-antibody mediated. Meanwhile,the two-hit model and threshold model are supported by many animal studies.So the most effective prevention is a restrictive transfusion strategy,and making exclusion policy that exclude high-risk donor with multiparous history can also reduce the incidence of TRALI.In addition,either the clinical department or blood service are discussing if some other strategies such as“patient-tailored transfusion policy”and “pooling of plasma”have value in reducing the incidence of TRALI.

Key words: Transfusion related acute lung injury（TRALI）, Pathogenesis, Prevention policy

中图分类号:

R457.1

邱丽. 输血相关急性肺损伤的发病机制及预防策略[J]. 临床输血与检验, 2017, 19(2): 205-209.

QIU Li. The Pathogenesis and Prevention Strategies of Transfusion Related Acute Lung Injury[J]. JOURNAL OF CLINICAL TRANSFUSION AND LABORATORY MEDICINE, 2017, 19(2): 205-209.

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输血相关急性肺损伤的发病机制及预防策略

The Pathogenesis and Prevention Strategies of Transfusion Related Acute Lung Injury

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