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临床输血与检验

临床输血与检验 ›› 2017, Vol. 19 ›› Issue (3): 272-275.DOI: 10.3969/j.issn.1671-2587.2017.03.017

• 临床检验 • 上一篇    下一篇

经纤维支气管镜局部注射辅助治疗耐多药肺结核效果评价

高云   

  1. 071000 保定,河北大学附属医院北院
  • 收稿日期:2016-10-16 出版日期:2017-06-20 发布日期:2017-06-23
  • 作者简介:高云（1975-）,男,副主任医师,学士,（Tel）0312-5981818,13703121377。

Therapeutic Efficacy of Local Injections Via Fiberoptic Bronchoscopy for Patients with Multi-drug Resistant Tuberculosis

GAO Yun   

  1. Affiliated Hospital of Hebei Unibersity 071000
  • Received:2016-10-16 Online:2017-06-20 Published:2017-06-23

PDF

674

被引次数

2

摘要： 目的 探讨经纤维支气管镜局部注射辅助治疗耐多药肺结核的效果及对免疫功能的影响。方法 选择2013年3月~2014年3月本院收治的98例耐多药肺结核患者,按照治疗方案不同分为实验组50例（3DVThAE/15DVThE方案+纤维支气管镜局部注射治疗）和对照组48例（3DVThAE/15DVThE方案治疗）,比较2组治疗效果及免疫功能指标的水平。结果 实验组患者3个月、6个月、12个月痰菌转阴率均明显高于对照组,差异有统计学意义（P<0.05）;实验组患者病灶吸收和空洞缩小总有效率均明显高于对照组,差异有统计学意义（P<0.05）;实验组患者治疗后CD4+、CD4+/CD8+和IFN-γ水平明显高于对照组,CD8+和IL-4水平明显低于对照组,差异有统计学意义（P<0.05）。结论 经纤维支气管镜局部注射辅助治疗耐多药肺结核的临床疗效显著,且能改善患者免疫功能,可作为临床治疗的优选方案。

关键词: 纤维支气管镜, 局部注射, 耐多药肺结核

Abstract: Objective To explore the efficacy of local injections via fiberoptic bronchoscopy for the patients with multi-drug resistant tuberculosis. Methods Ninety eight cases of patients with multi-drug resistant tuberculosis were divided into the experiment group （50 cases,3DVThAE/15DVThE+local injections via fiberoptic bronchoscopy） and control group（48 cases,3DVThAE/15DVThE only）. The clinical effects and immune status of the patients were compared. Results The sputum negative conversion rates for 3 months,6 months,and 12 months in the experiment group were higher than those in the control（P<0.05）. The total rates of lesions disapperance and cavity reduction of the lung were higher in the experiment group than those in the control（P<0.05）. The higher levels of CD4+,CD4+/CD8+ and IFN-γ expression were seen in the experiment group than the control（P<0.05）. The number of CD8+ was decreased in the experiment group （P<0.05）. In contrast,IL-4 level was found to be reduced in the experiment group（P<0.05）. Conclusion Local injections via fiberoptic bronchoscopy is promising for the treatment of patients with multi-drug resistant tuberculosis,

Key words: Fiberobronchoscopy, Local injection, Multi-drug resistant tuberculosis

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