宫颈上皮内瘤变筛查中TCT与HPV的检验价值

doi:10.3969/j.issn.1671-2587.2018.02.018

临床输血与检验 ›› 2018, Vol. 20 ›› Issue (2): 166-168.DOI: 10.3969/j.issn.1671-2587.2018.02.018

宫颈上皮内瘤变筛查中TCT与HPV的检验价值

杨玲

537100 广西贵港市人民医院检验科

收稿日期:2017-10-12 出版日期:2018-04-20 发布日期:2018-04-25
作者简介:杨玲（1978-）,女,广西贵港人,主管技师,学士,主要从事临床免疫与PCR检验研究,（E-mail）yangling65y@163.com。

Evaluation of TCT and HPV Detections for Screening of Cervical Intraepithelial Neoplasia

YANG Ling

Department of Laboratory,Guigang People's Hospital,Guangxi,537100

Received:2017-10-12 Online:2018-04-20 Published:2018-04-25

摘要/Abstract

摘要： 目的探究在宫颈上皮内瘤变筛查中液基薄层细胞检验（TCT）和人乳头状瘤病毒检验（HPV）的应用价值。方法回顾性分析2012年1月~2015年3月674例宫颈上皮内瘤变患者资料,所有患者均接受TCT与HPV检验,并经组织活检证实,将两种检验方法结合后分析各种检验方案的差异。结果 674例患者中578例患者接受TCT检验,508例患者接受HPV检验,其中TCT检验结果显示阳性509例,阳性率88.1%,HPV检验结果显示阳性459例,阳性率90.4%,其中444例患者同时进行TCT和HPV检验,两种检验结果均为阳性350例,阳性率78.8%;单一阳性90例,阳性率20.3%;总体阳性率99.1%,联合检验阳性率显著高于单一检验（P<0.05）,但TCT和HPV检验的阳性率对比,差异无统计学意义（P>0.05）。结论 TCT和HPV均可用于各个级别CIN患者的筛查,但联合应用能够显著提高阳性检出率,提高检验效能,避免漏检,值得在临床上推广和应用。

关键词: 宫颈上皮内瘤变, 液基薄层细胞检验, 人乳头状瘤病毒, 检验价值

Abstract: Objective To explore the value of thinprep cytology test （TCT） and human papilloma virus （HPV） test in cervical intraepithelial neoplasia （CIN） screening. Methods A retrospective analysis was performed by using the data of 674 patients with neoplasia from 2012 to 2015,and all patients received TCT and HPV tests and confirmed diagnoses were made by biopsy. Results Five hundred and seventy eight of 674 cases received TCT tests and 508 cases received HPV tests. TCT or HPV tests were positive in 509 （88.1%） and 459 cases （90.4%）,respectively. Three hundred and fifty of 444 cases （78.8%） were found to have overlaped positivity,and 90 cases were TCT positive （20.3%）,with general positive rate of 99.1%. The results showed that a combined testing gives rise to a higher positive rate than the single test（P<0.05）although no significant difference was noted between TCT and HPV（P>0.05）. Conclusion Combination tests of both TCT and HPV may improve the efficacy and avoid missed diagnosis in CIN screening.

Key words: Cervical intraepithelial neoplasia, Liquid based cytology test, Human papilloma virus, Test value

中图分类号:

R737.33R446

杨玲. 宫颈上皮内瘤变筛查中TCT与HPV的检验价值[J]. 临床输血与检验, 2018, 20(2): 166-168.

YANG Ling. Evaluation of TCT and HPV Detections for Screening of Cervical Intraepithelial Neoplasia[J]. JOURNAL OF CLINICAL TRANSFUSION AND LABORATORY MEDICINE, 2018, 20(2): 166-168.

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宫颈上皮内瘤变筛查中TCT与HPV的检验价值

Evaluation of TCT and HPV Detections for Screening of Cervical Intraepithelial Neoplasia

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