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临床输血与检验

临床输血与检验 ›› 2019, Vol. 21 ›› Issue (1): 53-55.DOI: 10.3969/j.issn.1671-2587.2019.01.018

• 临床检验 • 上一篇    下一篇

PreS1抗原和HBV血清学标志物与HBV DNA的相关性及临床意义*

杨传信   

  1. 201499 上海市奉贤区中心医院
  • 收稿日期:2018-08-19 出版日期:2019-02-20 发布日期:2019-01-28
  • 作者简介:杨传信（1983-）,男,安徽人,主管技师,学士,主要从事微生物及免疫学检验工作,（Tel）18964900456（E-mail）1960483851@qq.com。
  • 基金资助:
    本课题受上海市卫生和计划生育委员会青年项目（No. 20164Y0156）资助

Correlation and Clinical Significance of PreS1 Antigen and HBV Serological Markers and HBV-DNA

YANG Chuan-xin   

  1. Central Hospital of Shanghai Fengxian District, 201499
  • Received:2018-08-19 Online:2019-02-20 Published:2019-01-28

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摘要： 目的 研究前S1抗原（PreS1）、乙型肝炎病毒核酸（HBV DNA）及HBV血清标志物（HBV-M）之间关联,探讨三者在在HBV感染诊疗的临床应用价值。方法 回顾性分析2016年1月~2018年6月本院1 184例HBV感染疑似患者PreS1、HBV DNA及HBV-M的检测情况。结果 大三阳组PreS1与其他6组比较,差异均存在统计学意义（χ2=87.597,111.736,216.866,168.015,421.362,324.532,202.062,P<0.05）;“大三阳”组HBV DNA阳性率与其他6组比较,差异均有统计学意义（χ2=131.174,254.110,216.866,158.416,402.563,306.883,181.859,P<0.05）;PreS1及HBV DNA阳性率远高于其他各组; PreS1与HBeAg的关联有统计学意义（χ2=478.981,P<0.001）,PreS1与HBV DNA的关联也有统计学意义（χ2=909.450,P<0.001）;PreS1与HBeAg诊断符合率为85.13%;Pre与HBV DNA的诊断符合率为94.93%。HBeAg阳性乙肝患者HBV DNA平均病毒载量高于HBeAg阴性乙肝患者,差异有统计学意义（P<0.05）。结论 传统HBV血清学检测HBeAg与PreS1及HBV DNA具有一定的相关性,PreS1及HBV DNA更能准确的反映HBV的复制状态及传染性。

关键词: 前S1抗原, 乙型肝炎病毒核酸, 乙型肝炎病毒血清标志物

Abstract: Objective To explore the clinical application value of the three parameter in the diagnosis and treatment of hepatitis B virus infection ,we analysed the relationship between pre S1 antigen (PreS1), hepatitis B virus nucleic acid (HBV-DNA) and hepatitis B virus serum markers (HBV-M). Methods A retrospective analysis was conducted on the detection data of PreS1, HBV-DNA and HBV-M in 1 184 patients with suspected HBV infection in our hospital from January 2016 to June 2018. Results There was a statistical difference between the PreS1 and the other six groups (χ2=87.597,111.736,216.866,168.015,421.362,324.532,202.062, P<0.05), and the positive rate of HBV-DNA in the "big three positive" group was significantly different from that of the other six groups (χ2=131.174,254.110,216.866,158.416,402.563,306.883. 181.859, P<0.05), the positive rate of PreS1 and HBV-DNA was much higher than that of other groups, and there was a significant association between PreS1 and HBeAg (χ2=478.981, P<0.001), and there was a significant correlation between PreS1 and HBV-DNA (χ2=909.450, P<0.001),the diagnostic coincidence rate between PreS1 and HBeAg was 85.13% and that between pre and HBV-DNA was 94.93%. the average viral load of HBV-DNA in patients with positive hepatitis B was higher than that in HBeAg negative hepatitis B patients (P<0.05). Conclusion the traditional serological detection of hepatitis B virus (HBV) HBeAg has certain correlation with PreS1 and HBV-DNA. PreS1 and HBV-DNA can more accurately reflect the replication status and contagion of HBV.

Key words: Pre S1 antigen, Hepatitis B virus nucleic acid, Hepatitis B virus serum markers

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