关键词: 慢性盆腔炎, 裸花紫珠片, 白细胞介素-1β, 单核细胞趋化蛋白-1, 粒细胞-巨噬细胞集落刺激因子

Abstract: Objective To investigate the clinical efficacy of Callicarpa nudiflora, a Traditional Chinese Medical （TCM） tablet, on alleviation of chronic pelvitis via reducing inflammatory cytokines of IL-1β,MCP-1 and GM-CSF. Methods One hundred and twenty four patients were randomly divided into control group （62 cases） and treatment group （62 cases）. Patients in the control were intravenously given ceftriaxone sodium and metronidazole sodium chloride while those in the observation group were treated with the Chinese patient medicine tablets for four weeks in addition to the antibacterial agents. The disappear time of dominant clinical menifestations and their scoring were evaluated; IL-1β,MCP-1 and GM-CSF were measured. Results The efficiency of the TCM-combined treatments reached 91.9%, which was notably higher than that （77.4%, P<0.05） of the antibacterial agents administration in the control. The disappear time of temperature fell to normal, the pain in low abdominal and secretions of leukorrhea were significantly relieved with low syndrome scores in the patients with combined therapy when compared with those in the control （P<0.05） . Additionally, the levels of IL-1β,MCP-1 and GM-CSF in the patients of observation group were decreased following combined treatments（P<0.05）. Conclusion The combination of antibacterial agents with Callicarpa nudiflora tablets show a promising efficacy for treatment of chronic pelvic infections, and has ability to ameliorate inflammatory cytokines such as IL-1β,MCP-1 and GM-CSF.

Key words: Pelvic inflammatory disease, Huaihuazizhu tablets, IL-1β, MCP-1, GM-CSF