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临床输血与检验

临床输血与检验 ›› 2019, Vol. 21 ›› Issue (4): 368-371.DOI: 10.3969/j.issn.1671-2587.2019.04.009

• 临床输血 • 上一篇    下一篇

地塞米松联合咖啡酸片治疗ITP患者对PAIgG及GPⅡb/Ⅲa抗体的影响*

徐丹, 计成阜, 陈超, 姜金龙, 刘鑫, 王萍, 周海侠   

  1. 224400 江苏省盐城市阜宁县人民医院血液科（徐丹,计成阜,陈超,姜金龙,刘鑫,王萍）; 苏州大学附属第一医院血液科（周海侠）
  • 收稿日期:2018-06-24 出版日期:2019-08-20 发布日期:2019-08-28
  • 作者简介:徐丹（1981-）,男,江苏阜宁人,主治医师,学士,主要从事血小板减少症研究工作,（Tel）13770171413。
  • 基金资助:
    *本课题受江苏省盐城市医学科技发展计划项目（No. YK2017070）资助

The Effect of Dexamethasone Combinated with Caffeic Acid Tablet on PAIgG and GPⅡb/Ⅲa Levels in Patients with Primary Immune Thrombocytopenia

XU Dan, JI Cheng-fu, CHEN Chao, et al   

  1. Department of Hematology, Funing Hospital of Yancheng, Jiangsu 224400
  • Received:2018-06-24 Online:2019-08-20 Published:2019-08-28

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摘要： 目的 探讨地塞米松联合咖啡酸片治疗原发性免疫性血小板减少症（primary immune thrombocytopenia,ITP）对患者血小板相关抗体 (platelet-associated immunoglobulin ,PAIgG)及GPⅡb/Ⅲa抗体水平的影响。方法 将2014年8月~2017年3月本院收治的ITP患者80例随机分为2组,观察组与对照组各40例,其中对照组患者服用地塞米松,观察组服用地塞米松及咖啡酸。对比两组治疗效果、PAIgG及GPⅡb/Ⅲa抗体水平的差异。结果 两组患者治疗14 d、28 d、12 w后CR、R及NR人数比例间的差异无统计学意义;治疗前,两组出血评分、PAIgG及GPⅡb/Ⅲa抗体水平的组间差异无统计学意义（P>0.05）。治疗后,两组出血评分、PAIgG及GPⅡb/Ⅲa抗体水平明显低于治疗前 (P<0.05);其中,观察组出血评分[1（0~3.5）vs 2（0~5）]分、PAIgG阳性血小板百分率[（25.52±7.21）vs（36.18±8.79）]%、GPⅡb/Ⅲa抗体水平[（16.77±2.15）vs（21.49±1.58）]明显低于对照组(P均<0.05)。结论 地塞米松联合咖啡酸片治疗ITP患者与单独服用地塞米松组相比,疗效差异无统计学意义,但药物合用可有效改善患者出血症状,降低PAIg G及GPⅡb/Ⅲa抗体水平。

关键词: 地塞米松, 咖啡酸, 原发性免疫性血小板减少症, PAIgG, GPⅡ b/Ⅲ a

Abstract: Objective To investigate the effect of dexamethasone (DX) combinated with caffeic acid tablet (CAT) on PAIg G and GPⅡb/Ⅲa levels in patients with primary immune thrombocytopenia (ITP). Methods Eighty patients with ITP in the hospital were selected from August 2014 to March 2017 and randomly divided into two groups, with 40 cases in each. The control group only received CAT, while the observation group was given DX and CAT. Clinical efficacy and PAIg G and GPⅡb/Ⅲa levels were compared between the two groups. Results The CR, R and NR rates did not reveal any significant difference on d14, d28 and w12 after treatments. Similarly, the bleeding score, PAIg G and GPⅡb/Ⅲa levels showed no remarkable differences before treatments（P>0.05）but obviously decreased after treatments in the observation group compared with the control （P<0.05）. Conclusion Compared with dexamethasone treatment, dexamethasone combined with caffeic acid tablet did not improve the therapeutic outcomes in the treatment of ITP patients in terms of laboratory tests. However, the combination therapy can effectively ameliorate the bleeding symptoms and reduce the antibody levels of PAIg G and GPⅡb /Ⅲa.

Key words: Dexamethasone, Caffeic acid, Primary immune thrombocytopenia, PAIg G, GPⅡ b/Ⅲ a

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