Th17/Treg细胞与MDS

doi:10.3969/j.issn.1671-2587.2019.04.031

临床输血与检验 ›› 2019, Vol. 21 ›› Issue (4): 444-448.DOI: 10.3969/j.issn.1671-2587.2019.04.031

• 综述 • 上一篇

Th17/Treg细胞与MDS

刘竞, 陈乃耀

063000 唐山,河北省华北理工大学附属医院

收稿日期:2018-08-10 出版日期:2019-08-20 发布日期:2019-08-28
通讯作者: 陈乃耀,男,硕士,主任医师,主要从事血液学研究,（ E-mail）nychenncmc@163.com。
作者简介:刘竞（1993-）,女,在读硕士研究生,主要从事血液学研究,（ E-mail）18631577691@163.com。
基金资助:
*本课题受2014年政府资助临床医学优秀人才培养项目资助

Received:2018-08-10 Online:2019-08-20 Published:2019-08-28

摘要/Abstract

摘要： 骨髓增生异常综合征（myelodysplastic syndromes,MDS）是一组异质性造血干细胞恶性肿瘤,以造血缺陷相关的血细胞减少、髓样发育不良和髓内凋亡为特征,伴进展为急性骨髓性白血病的风险增加。尽管发现了许多与MDS临床表型有关的点突变,但并不能完全解释MDS的发病机制和临床表现。研究表明,不同免疫途径在MDS发病机制和疾病进展中起重要作用,并观察到多种自体免疫疾病和表现与MDS有关。现已证实,Th17细胞可引起自身免疫,而Tregs细胞抑制自身免疫;Th17细胞和Treg细胞共享一个由TGF介导的信号通路,因此,由炎性信号介导Th17细胞和Treg细胞的交互生成对自体免疫疾病发病至关重要。且研究发现,Th17细胞与Treg细胞与疾病严重程度及预后相关,可根据Th17细胞与Treg细胞数量、比例来评估病情。本文就Th17/Treg细胞生物学特点及其与MDS的关系及影响进行综述。

中图分类号:

刘竞, 陈乃耀. Th17/Treg细胞与MDS[J]. 临床输血与检验, 2019, 21(4): 444-448.

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Th17/Treg细胞与MDS

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