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临床输血与检验

临床输血与检验 ›› 2019, Vol. 21 ›› Issue (5): 499-501.DOI: 10.3969/j.issn.1671-2587.2019.05.016

• 临床检验 • 上一篇    下一篇

HbA2与红细胞指标对缺铁性贫血和α-地中海贫血的鉴别诊断价值

郭晖   

  1. 528300 广东省南方医科大学顺德医院
  • 收稿日期:2018-08-06 出版日期:2019-10-20 发布日期:2019-10-29
  • 作者简介:郭晖（1980-）,女,广东顺德人,主管检验师,学士,主要从事临床医学检验工作,（E-mail）zhaokxoe@126.com。

The Value of HbA2 and Indexes of Red Blood Cells in Differential Diagnosis of Iron Deficiency Anemia and α-Thalassemia

GUO Hui   

  1. Hospital of Southern Medical University,Shunde,Guangdong 528300
  • Received:2018-08-06 Online:2019-10-20 Published:2019-10-29

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摘要： 目的 分析检测缺铁性贫血（IDA）和α-地中海贫血（α-THAL）患者中HbA2与红细胞各指标含量,为该类贫血疾病的临床诊断提供参考。方法 2016年1月~2017年12月来本院例行产前检查的孕妇4 156例中筛选符合条件的体检正常组120例、IDA组240例和α-THAL组80例,对比分析3组患者HbA2及红细胞各指标含量。结果 与正常组比较,IDA组7项红细胞指标的含量明显改变,HbA2含量明显偏低; α-THAL组除RDW外,其余红细胞指标含量明显改变,HbA2含量明显偏低。RBC、MCV、RDW和HbA2含量在IDA组和α-THAL组之间明显不同。RDW对缺铁性贫血患者检测的特异性和灵敏度分别为77.5%和95.0%;MCV、RBC和HbA2对α-地中海贫血患者检测的特异性分别为81.3%、77.5%和83.8%,检测灵敏度分别为93.3%、86.7%和87.5%。结论 HbA2与红细胞各指标对于缺铁性贫血和α-地中海贫血与正常组鉴别能力较强,其中RDW在缺铁性贫血患者的鉴别中的特异性和灵敏度较高,HbA2结合SF在α-地中海贫血患者的鉴别中的特异性和灵敏度较高。

关键词: HbA2, 红细胞平均分布宽度, 缺铁性贫血, α地中海贫血

Abstract: Objective To analyze HbA2 level and indexes of red blood cells （RBCs） in patients with iron deficiency anemia （IDA） and alpha thalassemia （α-THAL） so as to provide a reference for the differential diagnosis of anemia.Methods A total of 4 156 pregnant women for routine prenatal examinations were screened in the hospital from 2016 to 2017,among them 120 cases of normal control,240 cases of IDA group and 80 cases of α-THAL group were collected. HbA2and RBCs of the pregnant women of the three groups were compared.Results Compared with the normal group,seven RBCs indexes in IDA group significantly changed,and the level of HbA2 decreases. The RBCs indexes in α-THAL group,except for RDW,were notably altered and HbA2 level was decreased. A significant difference of RBCs,MCV,RDW,and HbA2 contents was noted between IDA and α-THAL groups. The RDW detection gave rise to 77.5% of specificity and 95.0% of sensitivity whereas the detections of MCV,RBC,and HbA2 resulted in 81.3%,77.5%,and 83.8% of specificity and 93.3%,86.7%,and 87.5% of sensitivity,respectively.Conclusion sThe HbA2 and indexes of RBCs may help differenciate iron deficiency anemia from α-thalassemia. The RDW is highly specific and sensitive in identification of iron deficiency anemia. HbA2 combined with SF is quite useful for diagnosis of patients with α-thalassemia.

Key words: HbA2, Red blood cell distribution width, Iron deficiency anemia, Alpha thalassemia

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