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临床输血与检验

临床输血与检验 ›› 2018, Vol. 20 ›› Issue (1): 76-79.DOI: 10.3969/j.issn.1671-2587.2018.01.026

• 临床检验 • 上一篇    下一篇

DXH800红细胞新参数在缺铁性贫血中的应用

田民杰, 李艳   

  1. 211100 南京,江苏省南京市江宁医院检验科
  • 收稿日期:2017-08-28 出版日期:2018-02-20 发布日期:2018-02-28
  • 通讯作者: 李艳,（E-mail）pengqs520@163.com。
  • 作者简介:田民杰（1984-）,男,江苏泰州人,主管检验技师,学士,主要从事临床血液检验工作,（E-mail）13701580217@163.com。

The New Parameters of Erythrocyte Generated by DXH800 Hematology Analyzer in Clinical Application of Iron Deficiency Anemia

TIAN Min-jie, LI Yan   

  1. Clinical Laboratory of Jiangning Hospital,Nanjing from Jiangsu Province,Postcode 211100
  • Received:2017-08-28 Online:2018-02-20 Published:2018-02-28

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摘要： 目的 建立健康人群的低血红蛋白密度（low hemoglobin density,LHD）和小红细胞贫血因子（microcytic anemia factor,MAF）的正常参考区间,研究两参数在诊断缺铁性贫血中的临床价值。方法 随机选取180例健康体检人群,其中男性90例,女性90例;54例缺铁性贫血（iron-deficiency anemia,IDA）患者,50例非缺铁性贫血患者。方法应用UniCel®DxH 800血液分析系统进行血常规检测,根据分析参数的平均血红蛋白浓度（mean corpuscular hemoglobin concentration,MCHC）、平均红细胞体积（erythrocyte mean corpuscular volume,MCV）、血红蛋白（hemoglobin,Hb）,计算参数LHD和MAF。结果 健康对照组LHD均值为2.11%,95%可信区间为0.65%~3.79%。男性大于女性,差异有统计学意义（t=4.45,P<0.01）;MAF均值为130,95%可信区间为111.35~146.19。男性大于女性,差异有统计学意义（t=9.14,P<0.01）。IDA组LHD明显升高,均值26.19%,与健康对照组相比差异有统计学意义（t=10.93,P<0.01）,与非缺铁性贫血患者组相比差异有统计学意义（t=4.68,P<0.01）;MAF明显降低,均值78.88,与健康对照组相比差异有统计学意义（t=26.10,P<0.01）,与非缺铁性贫血患者组相比差异有统计学意义（t=7.60,P<0.01）。ROC曲线分析结果显示：当LHD取4.09%、MAF取109.9为CUT-OFF值时,诊断IDA的敏感度和特异性都比MCHC提高,MAF的灵敏度和特异性最好。结论 建立江宁区LHD和MAF参考范围,LHD、MAF检测对于IDA早期诊断有一定的临床价值。

关键词: 低血红蛋白密度, 小红细胞贫血因子, 可信区间, 缺铁性贫血

Abstract: Objective To establish normal reference range of LHD（low hemoglobin density） and MAF （Microcytic Anemia Factor） in the healthy crowds from Jiangning hospital,and to study clinical values in the two parameters' joint detection in the diagnosis of iron deficiency Anemia. Methods To select randomly 180 cases of healthy exam crowds,among which 90 cases were male,and the other 90 cases were female,54 cases of iron-deficiency anemia IDA and 50 patients with non iron deficiency anemia. Routine blood tests were operated by UniCe®DxH 800,and the hematology analyzer calculates the LHD and MAF,based on the analysis of parameters of MCHC （mean corpuscular hemoglobin concentration）,MCV（erythrocyte mean corpuscular volume）,and Hb（hemoglobin,Hb）.Results the average value of LHD in the healthy control was 2.11%,95% confidence interval of which was 0.65% ~ 3.79%. The LHD value of males was higher than that of females. The difference was statistically significant （t=4.45,P<0.01）. The average value of MAF was 130,95% confidence interval of which was 111.35 ~ 146.19. The MAF value of males was higher than that of females,the difference was statistically significant（t=9.14,P<0.01）. LHD in the IDA group was obviously higher,average of which was 26.19%,compared with the healthy control group,and the difference was statistically significant （t=10.93,P<0.01）;There were significant differences in the group of anemia patients with non iron deficiency anemia（t=4.68,P<0.01）.There was a significant decline in MAF,the average of which was 78.88,compared with the healthy control group,and the difference was statistically significant（t=26.10,P<0.01）.There were significant differences in the group of anemia patients with non iron deficiency anemia （t=7.6,P<0.01）. Receiveroperating characteristic（ROC） curve analysis for LHD and MAF in the diagnosis of IDA：cut-off 4.09% and 109.9.The sensitivity and specificity of diagnosis for IDA were higher than MCHC. The sensitivity and specificity of MAF were optimal. Conclusion To establish the reference rang of LHD and MAF in the area of jiangning.LHD and MAF for early diagnosis of IDA has certain clinical significance.

Key words: Low hemoglobin density, Microcytic anemia factor, Confidence interval, Iron deficiency anemia

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