• 中国科学论文统计源期刊
  • 中国科技核心期刊
  • 美国化学文摘(CA)来源期刊
  • 日本科学技术振兴机构数据库(JST)

临床输血与检验 ›› 2019, Vol. 21 ›› Issue (5): 524-526.DOI: 10.3969/j.issn.1671-2587.2019.05.023

• 临床检验 • 上一篇    下一篇

CA153和PLGF在胎盘早剥患者血清中的表达及临床意义

颜申姬, 周慧, 房笃智, 王敏, 张玲   

  1. 518101 广东省深圳市宝安区人民医院检验科
  • 收稿日期:2018-01-14 出版日期:2019-10-20 发布日期:2019-10-29
  • 作者简介:颜申姬(1981-),女,湖南娄底人,主管技师,学士,主要从事免疫学和分子生物学检验工作,(Tel)13417362426(E-mail)yanshenji1981@163.com。

Detection of CA153 and PLGF in the Serum of Patients with Placental Abruptionand Itsclinical Significance

YAN Shen-ji, ZHOU Hui, FANG Du-zhi, et al   

  1. Laboratory of People's Hospital of Shenzhen Baoan District,Guangdong 518101
  • Received:2018-01-14 Online:2019-10-20 Published:2019-10-29

摘要: 目的 了解糖类抗原153(carbohydrate antigen 153,CA153)和胎盘生长因子(placental growth factor,PLGF)在胎盘早剥产妇血清中的表达,并探讨其临床意义。方法 收集2014年3月~2017年8月来本院产科分娩的胎盘早剥产妇107例为研究组,取同期正常分娩产妇120例为对照组,采用DXI800全自动免疫发光分析法和酶联免疫吸附试验(enzyme linked immunosorbent assay,ELISA)分别检测产前和产后3个月产妇血清中CA153和PLGF浓度,并分析两组结果是否存在差异性。结果 研究组产妇产前血清中CA153浓度为(119.32±37.25)U/mL,明显高于对照组的(41.86±19.07) U/mL,差异有统计学意义(t=8.152,P<0.05),而PLGF浓度为(79.06±15.85)pg/mL,明显低于对照组的(132.37±45.26)pg/mL,差异有统计学意义(t=6.974,P<0.05);产后3个月,研究组产妇血清CA153和PLGF浓度分别为(43.92±21.35)U/mL和(121.52±42.67)pg/mL,与对照组比较差异均无统计学意义(t=1.038~1.203,P>0.05)。结论 胎盘早剥产妇产前血清中CA153浓度明显增高,PLGF浓度明显降低,而产后均恢复至正常产妇水平。因此,产前进行CA153和PLGF检测,对胎盘早剥诊断有一定的预估价值,值得推广应用。

关键词: 糖类抗原153, 胎盘生长因子, 胎盘早剥, 表达, 意义

Abstract: Objective To understand the carbohydrate antigen 153 (carbohydrate antigen 153,CA153) and placental growth factor(placental growth factor,PLGF) level in placental abruption maternal serum,and to explore its clinical significance.Methods Collected in March 2014 to August 2017 to shenzhen baoan district people's hospital obstetric delivery of 107 cases of placental abruption maternal as study group,120 cases of normal pregnant women as control group,DXI800 full automatic immune luminescence analysis and enzyme-linked immunosorbent assay (enzyme linked immunosorbent assay,ELISA) maternal prenatal and postnatal three months was detected in concentration of serum CA153 and PLGF,and analyze whether there is a difference between the two sets of results.Results Study group antenatal concentration of serum CA153 was(119.32±37.25)U/mL,significantly higher than the control group of(41.86±19.07)U/mL,difference was statistically significant (t=8.152,P<0.05),while PLGF concentration was(79.06±15.85)pg/mL,significantly lower than the control group of(132.37±45.26)pg/mL,difference was statistically significant(t=6.974,P<0.05); In the three months after delivery,the concentrations of CA153 andPLGF in the maternal serum of the study group were(43.92±21.35)U/mL and(121.52±42.67)pg/mL,There was no statistically significant difference between the control group and the control group (t=1.038~1.203,P>0.05).Conclusion Concentration of CA153 in the prenatal serum of placental abruption was significantly higher,and concentration of PLGF decreased significantly,and thepostpartum recovery was normal. Therefore,the prenatal process of CA153 and PLGF detection has a certain prediction value for the diagnosis of placental abruption,which is worth extending the application.

Key words: Carbohydrate antigen 153, Placental growth factor, Placental abruption, Express, Meaning

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