• 中国科学论文统计源期刊
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临床输血与检验

临床输血与检验 ›› 2019, Vol. 21 ›› Issue (6): 592-595.DOI: 10.3969/j.issn.1671-2587.2019.06.010

• 临床检验 • 上一篇    下一篇

妊娠期肝内胆汁淤积症患者血浆CG与TBA的表达及意义*

严妍, 王琦   

  1. 225600 江苏省高邮市人民医院检验科（严妍）;
    扬州市妇幼保健院妇产科（王琪）
  • 收稿日期:2018-05-19 出版日期:2019-12-20 发布日期:2019-12-25
  • 作者简介:严妍（1982-）,女,扬州高邮人,主治检验师,学士,主要从事甘胆酸与总胆汁酸的相关性研究,（Tel）18796662829（E-mail）yan18796662829@163.com。
  • 基金资助:
    *本课题受江苏省卫生计生委科研课题（No. Z201524）资助

Significance of Plasma CG and TBA in Patients with Intrahepatic Cholestasis of Pregnancy

YAN Yan, WANG Qi   

  1. Department of Laboratory Diagnostics, Gaoyou Hospital, Jiangsu 225600
  • Received:2018-05-19 Online:2019-12-20 Published:2019-12-25

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摘要： 目的 探究妊娠期肝内胆汁淤积症（intrahepatic cholestasis of pregnancy,ICP）患者血浆甘胆酸（cholyglycine,CG）与总胆汁酸（total bile acid,TBA）的表达水平及意义,为ICP的临床诊治提供理论依据。方法 选取2015年1月~2017年12月于本院妇产科就诊并住院生产的80例ICP患者及80例身体健康的住院孕产妇,分别设为观察组与对照组,比较两组孕产妇血浆CG、TBA水平及围生儿并发症情况。ICP患者按不同CG、TBA水平进行分组,比较围生儿并发症情况。结果 观察组血浆CG、TBA水平均高于对照组,差异有统计学意义（P<0.05）;观察组胎儿窘迫、早产、新生儿窒息、新生儿死亡发生率均高于对照组,差异有统计学意义（P<0.05）;ICP患者血清CG水平越高胎儿窘迫、早产、新生儿窒息发生率越高,差异有统计学意义（P<0.05）;ICP患者血清TBA水平越高,胎儿窘迫、早产、新生儿窒息发生率越高,差异有统计学意义（P<0.05）。结论 ICP患者血浆CG、TBA水平高于正常孕产妇,CG、TBA水平检测可用于ICP的临床诊断并预测病情变化,对围生儿预后也具有预测作用。

关键词: 妊娠期肝内胆汁淤积症, 甘胆酸, 总胆汁酸, 表达水平

Abstract: Objective To investigate the level and significance of plasma cholyglycine （CG） and total bile acid （TBA） in intrahepatic cholestasis of pregnancy （ICP） which may provide a basis for the clinical diagnosis and treatment of ICP.Methods Eighty ICP patients and 80 healthy pregnant women were selected from 2015 to 2017 and were divided into observation group and control group. The plasma levels of CG,TBA and perinatal complications in the two groups were compared. ICP patients were grouped according to the levels of CG and TBA,and the perinatal complications were compared. Results The levels of serum CG and TBA in the observation group were significantly elevated when compared with those in the control （P<0.05）. The incidence of fetal distress,premature birth,neonatal asphyxia and neonatal death were significantly higher in the observation group than those in the control （P<0.05）. The incidence of fetal distress,premature delivery and neonatal asphyxia increased with the high level of CG （P<0.05）. The level of TBA in patients with ICP was found to be in parallel with the incidence of fetal distress,premature delivery and neonatal asphyxia （P<0.05）. Conclusion Patients with ICP have a high level of serum CG and TBA compared with normal pregnancies. Detection of CG and TBA is useful for clinical diagnosis and prognosis of ICP.

Key words: Intrahepatic cholestasis of pregnancy, Cholyglycine, Total bile acid

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