关键词: 妊娠期肝内胆汁淤积症, 总胆汁酸, 脐血总胆汁酸, 围生儿结局

Abstract: Objective To investigate the relationship between the total serum bile acid （TSBA） and its value in pregnant women with intrahepatic cholestasis of pregnancy,and to analyze the influence of bile acid in cord blood on the outcomes of perinatal infants. Methods Clinical data of 123 cases were collected from Dec 2015 to May 2017 and the TSBA and transaminase were detected. The frequencies of perinatal complications were analyzed. The pregnant women were divided into two groups based on the level of TSBA and their clinical menifestations. Group 1 included the patients with 10-40 mol/L TSBA and skin itching whereas group 2,with 40 mol/L TSBA and severe pruritus associated with recurrent ICP and multiple pregnancy risk factors. Ninety six cases of normal pregnant women were taken as control. Results The pregnant women of both groups showed a high TSBA level compared with the control （P<0.05）. A positive correlation of bile acid level was found between the neonatal cord blood and maternal peripheral blood （r=0.903,P<0.05）. Patients of group 2 had high frequencies of premature birth,neonatal asphyxia,amniotic fluid contamination. Conclusion Neonatal perinatal complications in severe ICP pregnant women were frquently noted and grading of intrahepatic cholestasis during pregnancy may help determine the perinatal prognosis.

Key words: Intrahepatic cholestasis of pregnancy, Total bile acids, Cord blood, Perinatal outcomes