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临床输血与检验

临床输血与检验 ›› 2017, Vol. 19 ›› Issue (1): 67-70.DOI: 10.3969/j.issn.1671-2587.2017.01.019

• 临床检验 • 上一篇    下一篇

老年戊型肝炎患者肝功能分析*

鲁真真, 童书青, 栾芳, 鞠瑛, 张炳昌   

  1. 250021 济南,山东大学附属省立医院检验科
  • 收稿日期:2016-08-12 出版日期:2017-02-20 发布日期:2017-03-02
  • 通讯作者: 张炳昌,（E-mail）sdluzhenzhen@126.com。
  • 作者简介:鲁真真（1983-）,女,山东济南人,检验师,学士,主要从事分子免疫与免疫技术研究,（Tel）15168860823（E-mail）sdluzhenzhen@126.com。
  • 基金资助:
    *本课题受国家自然科学基金青年基金（No.81101484）、山东省自然科学基金（No.2R2011HM019）、山东省优秀中青年科学家科研奖励基金（No; BS2011SW035）资助

The Influence of Hepatitis E on Liver Function in the Elderly Patients

LU Zhen-zhen, TONG Shu-qing, LUAN Fang, et al   

  1. Department of Clinical laboratory,Shandong Provincial Hospital Affiliated to Shandong University Jinan 250021
  • Received:2016-08-12 Online:2017-02-20 Published:2017-03-02

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摘要： 目的 探讨戊型肝炎对老年人肝功能的损害。方法 收集戊型肝炎患者208例,根据年龄、性别分组,检测肝功能相关指标：谷丙转氨酶（ALT）、谷草转氨酶（AST）、γ-谷氨酰转肽酶（GGT）、总胆汁酸（TBA）、前白蛋白（PA）、白蛋白（ALB）、总胆红素（TBIL）、直接胆红素（DBIL）,并与100例健康人检测结果进行比较。结果 戊肝患者的AST、ALT、GGT、TBA、TBIL、DBIL检测均值明显高于健康人,PA、ALB低于健康人;50岁以上戊型肝炎患者AST、ALT、PA、ALB检测均值明显低于50岁以下戊肝患者,TBIL、DBIL检测均值明显高于50岁以下戊肝患者,且P<0.05,GGT、TBA的差异无统计学意义;老年男性戊肝患者的AST、ALT、GGT、PA、TBIL、DBIL检测均值明显高于老年女性戊肝患者,TBA、ALB的差异无统计学意义。结论 戊型肝炎病毒感染对肝功能的损害严重,老年人比青壮年肝损害严重、黄疸程度重且易发生瘀胆,老年男性患者相对较多且对肝脏损害比老年女性严重。

关键词: 戊型肝炎, 谷丙转氨酶, 谷草转肽酶, γ-谷氨酰转肽酶, 总胆汁酸, 总胆红素, 直接胆红素, 白蛋白, 前白蛋白

Abstract: Objective To investigate the damage of the hepatitis E to liver function in the elderly patients. Method sA total of 208 patients with hepatitis E were recruited and grouped according to age and gender. Indexes of liver function,including AST,ALT,GGT,TBA,PA,ALB,TBIL and DBIL were tested and then compared with those of 131 patients with chronic hepatitis B and 100 healthy control subjects. Results Compared with 131 patients with chronic hepatitis B and 100healthy control subjects,the levels of AST,ALT,GGT,TBA,TBIL,DBIL were higher in the patients with hepatitis E,while the levels of PA and ALB were lower in hepatitis E patients. The levels ofAST,ALT,PA and ALB in the patients over 50 years old （62.8±6.9） were lower than patients under 50 years old （62.8±6.9）,and the levels of TBIL and DBIL in the patients over 50 years old （62.8±6.9） were higher than patients under 50 years old （62.8±6.9）. There was no significantly statistical difference in the levels of GGT and TBA. The levels of AST,ALT,GGT,PA,TBIL and DBIL in male were higher than female,while the levels of TBA,and ALB were not significantly different. Conclusion The damage of hepatitis E to liver function is serious,especially for older patients and male patients. In addition,older patients had more serious jaundice and were prone to cholestasis.

Key words: Hepatitis E, ALT, AST, GGT, TBA, TBIL, DBIL, ALB, PA

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