关键词: 人乳头瘤病毒, HPV基因亚型, HPV疫苗, 宫颈癌

Abstract: Objective To analyze the infection status of human papillomavirus （HPV） in outpatient department of obstetrics and gynecology of a hospital in Hefei. Methods The cervical exfoliated cells were collected from 6 912 obstetrics and gynecology outpatient patients in 2018,DNA was extracted,HPV genotypes were detected,and infection rates and subtypes were analyzed. Results 2 627 were found to be HPV positive from 6 912 female patients,with a total positive rate of 38.0%. Among them,the high-risk HPV52 infection rate was 8.0%,the total positive rate and high-risk infection rate were 53.02% and 50.48% in the group of 56 years old above,and the total positive rate and high-risk infection rate were 33.09% and 29.96% respectively in the group 26~35 years old. As the number of infection types increased,the infection rate of each group decreased. The rate of single infection was the highest,it was 1 782 cases （25.78%）,that is, and the rate of multiple infection was the lowest,it was 236 cases （3.41%）, Conclusion There are different e distributions of HPV in outpatients of this hospital in type and age,and the infection is mainly high-risk type and single infection,which provides good theoretical support for the selection of HPV vaccination in this region.

Key words: Human papillomavirus, HPV genotype, HPV vaccine, Cervical cancer