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临床输血与检验

临床输血与检验 ›› 2019, Vol. 21 ›› Issue (6): 582-585.DOI: 10.3969/j.issn.1671-2587.2019.06.007

• 临床检验 • 上一篇    下一篇

血清抗C1q抗体在系统性红斑狼疮及狼疮性肾炎中的临床诊断价值*

张小云, 姜玉章, 唐朝贵, 张迎梅, 刘蓓蓓, 连建春   

  1. 223300 南京医科大学附属淮安第一医院
  • 收稿日期:2018-10-18 出版日期:2019-12-20 发布日期:2019-12-25
  • 通讯作者: 连建春,男,主管技师,硕士,主要从事疾病的病原生物学及病理生理研究,（ E-mail）ljc861222@126.com。
  • 作者简介:张小云（1987-）,女,江苏淮安人,主管技师,硕士,主要从事免疫及分子生物学,（ E-mail）xyzhang2009@126.com。
  • 基金资助:
    *本课题受南京医科大学科技发展基金（No.2016NJMU144）资助

The Clinical Diagnostic Value of Serum Anti-C1q Antibody Level in SLE and LN Patients

ZHANG Xiao-yun, JIANG Yu-zhang, TANG Chao-gui, et al   

  1. The Affiliated Huaian No.1 People,s Hospital of Nanjing Medical University,223300
  • Received:2018-10-18 Online:2019-12-20 Published:2019-12-25

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摘要： 目的 探讨系统性红斑狼疮（systemic lupus erythematosus,SLE）患者血清抗C1q抗体与疾病活动及狼疮性肾炎（lupus nephritis,LN）的相关性。方法 采用ELISA法测定110 例SLE患者和60例正常对照组血清中抗C1q抗体的水平。110例SLE患者按LN判定标准分为LN组（41例）和非LN组（69例）。比较分析其与补体C3、C4、超敏C反应蛋白（hypersensitive C-reactive protein,hs-CRP）及疾病活动性指标抗双链 DNA（anti-double-stranded DNA antibody,anti-dsDNA）抗体的相关性,并通过联合检测抗核小体抗体（anti-nucleosome antibodies,AnuA）及抗dsDNA抗体判断其在LN中的临床价值。结果 SLE患者中血清抗C1q抗体水平高于正常对照组[（11.90±23.83）U/mL vs（2.73±4.18）U/mL,P<0.05]。LN患者血清中抗C1q抗体水平与抗dsDNA抗体、hs-CRP水平呈显著正相关,与补体C3、C4含量水平呈显著负相关。联合检测抗C1q抗体、抗dsDNA抗体和AnuA显著提高LN的诊断价值。结论 抗C1q抗体水平能反映SLE的疾病活动程度,并与SLE肾损害相关,联合检测抗C1q抗体、抗dsDNA抗体和AnuA有助于LN的诊断。

关键词: 抗C1q抗体, 系统性红斑狼疮, 狼疮性肾炎

Abstract: Objective To detect the associations between anti-C1q antibody and systemic lupus erythematosus（SLE）and that between anti-C1q antibody and lupus nephritis（LN）．Methods The Anti-C1q antibody were measured using ELISA kit from 110 cases of SLE patients（SLE group） and 60 cases of healthy people（normal control group）. The 110 SLE patients were divided into LN group with 41 patients and non LN group with 69 patients. The serum levels of Anti-C1q,anti-dsDNA antibody and biochemical markers of the two groups were detected,and the result were analyzed. Results The serum anti-C1q antibody level of SLE group was significantly higher than that of normal control group[（11.90±23.83）U/mL vs（2.73±4.18）U/mL,P<0.05]．Serum level of anti-C1q antibody in LN group showed a strongly positive correlation with anti-dsDNA antibody and showed a negative correlation with C3 and C4 level.Conclusion Anti-C1q antibody would be helpful to characterize the disease activity of SLE,and is associated with SLE kindey damage. The combined detection of serum anti-C1q antibody,AnuA and anti-dsDNA antibody can improve LN diagnostic specificity.

Key words: Anti-C1q antibody, Systemic lupus erythematosus, Lupus nephritis

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