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临床输血与检验

临床输血与检验 ›› 2019, Vol. 21 ›› Issue (6): 612-615.DOI: 10.3969/j.issn.1671-2587.2019.06.015

• 临床检验 • 上一篇    下一篇

心肺复苏联合丹参川芎嗪注射液治疗急诊颅脑损伤患者的效果及对相关生化指标的影响*

沈桂芳, 沈华   

  1. 224100 江苏省盐城市大丰区急救医疗站
  • 收稿日期:2018-10-21 出版日期:2019-12-20 发布日期:2019-12-25
  • 作者简介:沈桂芳（1974-）,女,江苏大丰人,副主任医师,本科,主要从事急诊急救方面工作,（Tel）15151080828（E-mail）mnbp78@163.com。
  • 基金资助:
    *本课题受盐城市医学科技发展计划项目（No.YK20160-77）资助

Effect of Cardiopulmonary Resuscitation Combined with Salvia Miltiorrhiza Ligustrazine Injection on Patients with Acute Craniocerebral Injury and its Effect on GCS Score and Apache Ⅱ Score

SHEN Gui-fang, SHEN Hua   

  1. Emergency medical station in Dafeng District,Yancheng City,Jiangsu 224100
  • Received:2018-10-21 Online:2019-12-20 Published:2019-12-25

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摘要： 目的 研究心肺复苏联合丹参川芎嗪注射液治疗急诊颅脑损伤患者的效果及对相关生化指标的影响。方法 选取2013年3月~2018年3月本院收治符合纳入标准的152例患者,按照随机数字表法分为观察组（n=76例）和对照组（n=76例）。对照组给予心肺复苏及对症支持治疗,观察组在对照组的基础上给予丹参川芎嗪注射液治疗。治疗7天。比较两组患者血流动力学指标、乳酸、血糖、GCS评分、APACHEⅡ评分、脑水肿面积变化及预后。结果 治疗前,两组患者TK、Fi、MST、乳酸、血糖、APTT、TT、PT水平、脑水肿面积无差异（P>0.05）。经过治疗,观察组患者MST、Fi、乳酸、血糖、APTT、TT、PT水平、脑水肿面积均低于对照组（t=8.262,P<0.05;t=7.757,P<0.05;t=10.127,P<0.05;t=3.526,P<0.05;t=9.162,P<0.05;t=8.447,P<0.05;t=9.142,P<0.05;t=29.015,P<0.05）;观察组患者TK水平高于对照组（t=9.698,P<0.05）。治疗3个月后,观察组的良好及中度残疾率为76.32%,高于对照组的55.26%（χ2=7.480,P<0.05）。结论 心肺复苏联合丹参川芎嗪注射液治疗急诊颅脑损伤具有良好的临床效果,可改善患者的日常生活能力,改善患者的预后。

关键词: 心肺复苏, 丹参川芎注射液, 颅脑损伤, GCS评分, APACHEⅡ, 评分

Abstract: Objective To study the clinical effect of cardiopulmonary resuscitation combined with salvia miltiorrhiza ligustrazine injection in the treatment of emergency craniocerebral injury and its effect on GCS score and Apache Ⅱ score.Methods152 patients admitted in our hospital from March 2013 to March 2018 were randomly divided into two groups: observation group （n=76） and control group （n=76）.The control group was treated with cardiopulmonary resuscitation and symptomatic support,while the observation group was treated with salvia miltiorrhiza ligustrazine injection on the basis of the control group.Treatment 7 days. The indexes of hemodynamics,lactic acid,GCS and Apache Ⅱ,brain edema area and prognosis were compared between the two groups.Results Before treatment,there was no difference in TK,Fi,MST,lactic acid,blood glucose,APTT,TT,PT level and brain edema area between the two groups （P>0.05）. After treatment,the levels of MST,Fi,lactic acid,blood glucose,APTT,TT,PT and brain edema in the observation group were lower than those in the control group（t=8.262,P<0.05;t=7.757,P<0.05;t=10.127,P<0.05;t=3.526,P<0.05;t=9.162,P<0.05;t=8.447,P<0.05;t=9.142,P<0.05;t=29.015,P<0.05）.The level of TK is higher in the observation groupthan that in the control group（t=9.698,P<0.05）.After 3 months of treatment,the rate of good and moderate disability in the observation group was 76.32%,which was higher than that in the control group （55.26%）（χ2=7.480,P<0.05）.Conclusion Cardiopulmonary resuscitation combined with salvia miltiorrhiza ligustrazine injection has a good clinical effect in the treatment of emergency craniocerebral injury.

Key words: Cardiopulmonary resuscitation, Radix Salviae Miltiorrhizae Chuanxiong injection, Craniocerebral injury, GCS score, Apache Ⅱ, score

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