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临床输血与检验

临床输血与检验 ›› 2020, Vol. 22 ›› Issue (1): 68-70.DOI: 10.3969/j.issn.1671-2587.2020.01.016

• 临床检验 • 上一篇    下一篇

尼达尼布对肺纤维化患者内皮素-1、血管紧张素的影响

张秀, 杨三春   

  1. 635000 四川省达州市中西医结合医院呼吸内科
  • 收稿日期:2018-06-14 出版日期:2020-02-20 发布日期:2020-02-28
  • 作者简介:张秀(1980-),女,四川达州人,主管护师,学士,主要从事肺纤维的基础与临床研究工作,(Tel)13730797171(E-mail)3278722468@qq.com。

Effect of Nintedanib on Serum Level of Endothelin-1 and Angiotensin in Patients with Pulmonary Fibrosis

ZHANG Xiu, YANG San-chun   

  1. Department of Respiratory Medicine,Dazhou Hospital of Traditional Chinese and Western Medicine,Sichuan 635000
  • Received:2018-06-14 Online:2020-02-20 Published:2020-02-28

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摘要： 目的 分析尼达尼布对肺纤维化患者内皮素-1、血管紧张素的影响,评价其疗效。方法 以2016年2月~2018年2月医院呼吸内科收治随访的肺纤维化患者80例,按照入院顺序、抽签随机分组,对照组、观察组各入组40例。2018年2月开始实施治疗,对照组采用常规治疗,观察组采用常规治疗联合尼达尼布治疗,4周后评价疗效和不良反应。结果 治疗后观察组疗效优于对照组(P<0.05)。治疗后,观察组与对照组内皮素-1、血管紧张素均低于治疗前,观察组低于对照组,差异有统计学意义(P<0.05)。治疗后,观察组与对照组胸片积分均低于治疗前,观察组低于对照组,差异有统计学意义(P<0.05)。观察组出现2例恶心和呕吐、食欲减退。结论 尼达尼布辅助治疗肺纤维化可增进疗效,抑制肺纤维化,能够下调内皮素-1、血管紧张素。

关键词: 肺纤维化, 内皮素-1, 血管紧张素, 尼达尼布

Abstract: Objective to analyze the effect of Nintedanib on endothelin-1 and angiotensin in patients with pulmonary fibrosis. Methods Eighty patients with pulmonary fibrosis were followed up from 2016 to 2018. The patients were randomly divided into the control group (n=40) and observation group (n=40) and treated with routine therapy combined with Nintedanib for 4 weeks. The efficacy and adverse reactions were monitored in hospital. Results The curative effect in the observation group was significantly increased compared to that in the control (P<0.05). The serum levels of endothelin-1 and angiotensin and scoring of chest radiographs, in the patients of both groups were decreased following treatments (P<0.05) but more remarkably in the observation group than the control group (P<0.05). Conclusion Nintedanib adjuvant treatment for pulmonary fibrosis may improve the curative effect and inhibit lung fibrosis, showing down-regulation of endothelin -1 and angiotensin production.

Key words: Pulmonary fibrosis, Endothelin-1, Angiotensin, Nintedanib

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