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临床输血与检验

临床输血与检验 ›› 2020, Vol. 22 ›› Issue (3): 308-311.DOI: 10.3969/j.issn.1671-2587.2020.03.021

• 临床检验 • 上一篇    下一篇

血清FGF-21和E-FABP与多囊卵巢综合征患者糖脂代谢指标相关性研究

吴秀成   

  1. 562400 贵州兴义,黔西南州中医院检验科
  • 收稿日期:2018-12-26 出版日期:2020-06-20 发布日期:2020-06-13
  • 作者简介:吴秀成（1962-）,男,贵州兴仁人,副主任技师,主要从事血液细胞形态学方面研究,（Tel）13985952687（E-mail）awesome123456@163.com。

Correlation between Glycolipid Metabolism and Serum Level of FGF-21 and E-FABP in Patients with Polycystic Ovary Syndrome

WU Xiu-cheng   

  1. Department of Laboratory,Qianxinan Hospital of Traditional Chinese Medicine,Xingyi,Guizhou 562400
  • Received:2018-12-26 Online:2020-06-20 Published:2020-06-13

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摘要： 目的 对多囊卵巢综合征患者体内血清表皮细胞型脂肪酸结合蛋白（血清E-FABP）和血清成纤维细胞生长因子21（血清FGF-21）与糖脂代谢指标的相关性进行研究。方法 选取我院2017年4月~2018年3月收治的多囊卵巢综合征患者74例,按照BMI（体质指数）将其分成肥胖组（n=43）与非肥胖组（n=31）,并选取同期BMI与患者相似的健康体检者36名为对照组。观察并比较三组患者血清FGF-21、E-FABP水平、糖代谢水平、脂代谢水平及其相关性。结果 肥胖组与非肥胖组患者的血清FGF-21、E-FABP水平明显高于对照组（P<0.05）,肥胖组患者血清FGF-21、E-FABP水平明显高于非肥胖组患者(P<0.05);非肥胖组与肥胖组患者糖代谢水平明显高于对照组（P<0.05）,肥胖组患者糖代谢水平明显高于非肥胖组患者（P<0.05）;非肥胖组与肥胖组患者LDL-C、FFA、TC、TG水平明显高于对照组（P<0.05）,非肥胖组与肥胖组患者HDL-C水平明显低于对照组（P<0.05）,肥胖组患者LDL-C、FFA、TC、TG水平明显高于非肥胖组患者（P<0.05）, 肥胖组患者HDL-C水平明显高于非肥胖组患者（P<0.05）;经数据分析发现,血清FGF-21、E-FABP水平与糖脂代谢指标呈直接相关（P<0.05）。结论 根据本研究发现,多囊卵巢综合征患者体内血清FGF-21和E-FABP水平能够反映患者糖脂代谢水平的变化,值得推广及应用。

关键词: 多囊卵巢综合征, 糖脂代谢指标, 血清成纤维细胞生长因子21, 血清表皮细胞型脂肪酸结合蛋白

Abstract: Objective To study the correlation between serum epidermal cell-type fatty acid binding protein (E-FABP) and serum fibroblast growth factor 21 (FGF-21) and glucose and lipid metabolic indicators in patients with polycystic ovary syndrome. Methods 74 patients with polycystic ovary syndrome admitted to our hospital from April 2017 to March 2018 were enrolled. According to BMI, they were divided into obese group (n=43) and non-obese group (n=31), and 36 healthy subjects with similar BMI to patients in the same period were selected as the control group. The serum levels of FGF-21, E-FABP, glucose metabolism and lipid metabolism in the three groups were observed and compared. Results The serum FGF-21 and E-FABP levels of the obese group and the non-obese group were significantly higher than those of the control group (P<0.05), and the serum FGF-21 and E-FABP levels of the obese group were significantly higher than those of the non-obese group (P<0.05). The glucose metabolism level of the non-obese group and the obese group was significantly higher than that of the control group (P<0.05), and the glucose metabolism level of the obese group was significantly higher than that of the non-obese group (P<0.05). Non-obese group and obesity group patients LDL - C, FFA, TC and TG levels are significantly higher than control group (P<0.05), level of HDL - C in non-obese group and obesity group was obviously lower than that in the control group (P<0.05), LDL - C, FFA, TC and TG levels are significantly higher in obese patients than non-obese patients (P<0.05), HDL - C levels in patients with obesity group was obviously higher than non-obese patients (P<0.05); According to the data analysis, the serum FGF-21 and E-FABP levels were directly correlated with the glycolipid metabolism indicators (P<0.05). Conclusion According to the findings of this study, the serum levels of FGF-21 and E-FABP in patients with polycystic ovary syndrome can reflect the changes of patients' glucose and lipid metabolism, which is worthy of promotion and application.

Key words: Polycystic ovarian syndrome, Glycolipid metabolism index, Serofibroblast growth factor 21, Serum epidermal cell fatty acid binding protein

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