关键词: 56~60周岁, 男性多次单采者, 血常规, 凝血功能, 血栓弹力图（TEG）

Abstract: Objective To explore the effect of regularly donating platelets from male multiple platelet donors aged 56 to 60 on their blood routine and coagulation function for a better guide to the elderly blood donation. Methods A total of 61 healthy male blood donors were selected from our center from November 2021 to August 2022, including 51 single platelet donors and 10 healthy whole blood donors who had not donated single platelet. The single platelet donors were all multiple donors (>10 times in the past year), among whom 12 donors aged 56 to 60 were assigned in Group A, and 39 donors aged 18 to 55 in Group B; healthy whole blood donors wihtout donation of single collected platelets were all aged 56 to 60 years old, with a total of 10 cases in Group C. Before collecting platelets, samples were taken and their blood routine, thromboelastogram (TEG), thrombin time (TT), Prothrombin time (PT), activated partial thromboplastin time (APTT) and fibrinogen (Fg) were tested. SPSS26.0 statistical analysis software was used for one way ANOVA analysis to compare its differences. Results Some differences were observed in Hb, Hct, PLT, MPV, and PCT (P<0.05), but not in other blood routine indicators (P>0.05) between groups A, B and C. There was no significant difference in blood routine indicators related to red blood cells, white blood cells, and platelets between Group A and Group B (P>0.05); compared with Group C, Hb, Hct in Group A showed a significant decrease, while PLT and PCT were increased. The difference between the two indicators was statistically significant (P<0.05), while other blood routine indicators did not differ (P>0.05). The R, K, Angle, and MA values of TEG (thromboelastography) in the three groups were within the normal reference range, with no significant difference in TEG indicators among Groups A, B, C, between Group A and Group B, or between Group A and Group C (P>0.05). TT, PT, and APTT in Group A and Group B were all within the normal reference range, but FIB showed a slight increase, and TT in Group C had a certain degree of increase while the other three indicators were normal; a significant difference was noted in TT and PT between groups A, B and C (P<0.05), but not in APTT and Fg.There was no significant difference in coagulation related indicators between Group A and Group B (P>0.05); TT and PT in Group A were lower than those in Group C, with a significant difference between the two groups (P<0.05); however, APTT and FIB showed no significant difference (P>0.05). Conclusion Regular donation of single platelet donors aged 56 to 60 does not have a pronounced impact on their blood routine and coagulation function. Considering paucity of single platelet resources, we should encourage multiple single platelet donors aged 56 to 60 to regularly donate single platelet. Meanwhile, however, it is also necessary to monitor the health of single collectors during the collection process.

Key words: 56 to 60 years old, Male multiple platelet donors, Blood routine, Coagulation function, Thromboelastogram, （TEG）