性别、年龄及ABO血型与血小板计数的相关性研究

doi:10.3969/j.issn.1671-2587.2026.04.022

临床输血与检验 ›› 2026, Vol. 28 ›› Issue (4): 608-613.DOI: 10.3969/j.issn.1671-2587.2026.04.022

性别、年龄及ABO血型与血小板计数的相关性研究

周世航, 刘健娣, 宋文倩, 范亚欣

大连市血液中心,辽宁大连 116001

收稿日期:2026-07-06 出版日期:2026-08-20 发布日期:2026-08-26
通讯作者: 范亚欣,主要从事血液免疫和血液安全研究,（E-mail）yaxinfan@163.com。
作者简介:周世航,主要从事血液免疫学研究,（E-mail）zshsail@163.com。

Correlation Study of Gender, Age, and ABO Blood Group with Platelet Counts

ZHOU Shihang, LIU Jiandi, SONG Wenqian, FAN Yaxin

Dalian Blood Center, Dalian 116001

Received:2026-07-06 Online:2026-08-20 Published:2026-08-26

摘要/Abstract

摘要： 目的探讨性别、年龄和ABO血型与血小板计数的关系。方法 4 657名健康献血者被纳入研究。血型采用血清学方法确定,血小板计数由自动血液分析仪测定。使用R软件（4.4.1）分析各项关联。结果男性平均血小板计数低于女性[男性：（243±45.3）×10⁹/L,女性：（259±50.2）×10⁹/L]（t=-10.15,P<0.001）。年龄与血小板计数在两性中均呈负相关（男性：r=-0.13,女性：r=-0.14;均P<0.001）。按年龄分层的趋势分析显示,总体随年龄下降;男性呈持续缓慢下降,而女性在30~49岁相对稳定。多元线性回归分析表明,性别、年龄和ABO血型为血小板计数的独立影响因子;B型献血者的血小板计数低于A型（P<0.05）。结论男性血小板计数低于女性。血小板计数随年龄缓慢下降,女性存在相对稳定的阶段。不同血型与血小板计数相关,提示其可能是影响血小板计数的一个遗传性状。

关键词: 性别, 年龄, ABO血型, 血小板计数

Abstract: Objective This study is to assess associations of sex, age, and ABO blood group with platelet counts. Methods A total of 4 657 healthy donors were enrolled. ABO groups were determined serologically and platelet counts measured by automated hematology analyzer. Associations were evaluated using R software (4.4.1). Results Mean platelet count was lower in males [(243±45.3)×10⁹/L] than that in females [(259±50.2)×10⁹/L] (t=-10.15, P<0.001). Age correlated negatively with platelet count in both sexes (male: r=-0.13, female: r=-0.14; both P<0.001). Age-stratified trend analysis showed an overall decline with age; males exhibited a steady gradual decrease, while females remained relatively stable between ages 30~49. Multivariable linear regression identified sex, age, and ABO group as independent predictors; group B had lower platelet counts than group A (P<0.05). Conclusion Platelet counts are lower in males than in females. Platelet counts decline slowly with age, with a relatively stable phase in females. ABO blood group is associated with platelet count; it may be a heritable trait affecting platelet count.

Key words: Sex, Age, ABO blood group, Platelet count

中图分类号:

R446.11

周世航, 刘健娣, 宋文倩, 范亚欣. 性别、年龄及ABO血型与血小板计数的相关性研究[J]. 临床输血与检验, 2026, 28(4): 608-613.

ZHOU Shihang, LIU Jiandi, SONG Wenqian, FAN Yaxin. Correlation Study of Gender, Age, and ABO Blood Group with Platelet Counts[J]. JOURNAL OF CLINICAL TRANSFUSION AND LABORATORY MEDICINE, 2026, 28(4): 608-613.

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性别、年龄及ABO血型与血小板计数的相关性研究

Correlation Study of Gender, Age, and ABO Blood Group with Platelet Counts

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