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临床输血与检验

临床输血与检验 ›› 2017, Vol. 19 ›› Issue (6): 574-577.DOI: 10.3969/j.issn.1671-2587.2017.06.013

• 临床检验 • 上一篇    下一篇

肝硬化患者血小板相关参数和凝血指标的检测价值研究*

程宜, 严志涵   

  1. 226500 江苏省如皋市人民医院检验科（程宜）;
    无锡市第五人民医院肝病科（严志涵）
  • 收稿日期:2017-05-11 出版日期:2017-12-20 发布日期:2017-12-13
  • 作者简介:程宜（1978-）,男,江苏如皋人,主管检验师,学士,主要从事临床检验工作,（Tel）15852512339（E-mail）cxyntfy@163.com。
  • 基金资助:
    *本课题受南京医科大学科技发展基金项目（No; 2013NJMU197）资助

Research on Examination Value of Platelet Indicators and Coagulation Indicator in Patients with Hepatic Cirrhosis

CHENG Yi, YAN Zhi-han   

  1. People's Hospital of Rugao, Wuxi No.5 People's Hospital 226500
  • Received:2017-05-11 Online:2017-12-20 Published:2017-12-13

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摘要： 目的 探究凝血指标与血小板相关参数在肝硬化研究中的应用价值,分析其临床意义,为肝硬化的诊治提供理论依据。方法 选择2014年1月~2015年1月于本院治疗的80例肝硬化患者（观察组）及80例体检正常者（对照组）,根据肝硬化Child-Pugh分级标准将观察组分为A、B、C级。应用血细胞分析仪及血凝仪检测血小板相关参数和凝血指标,血小板参数包括血小板体积分布宽度（PDW）、血小板计数（PLT）、平均血小板体积（MPV）、血小板压积（PCT）,凝血指标包括纤维蛋白原含量（FIB）、血浆凝血酶原时间（PT）、凝血酶时间（TT）、活化部分凝血活酶时间（APTT）。结果 观察组血小板PDW、PLT、MPV、PCT与对照组的差异,以及观察组凝血指标FIB、PT、TT、APTT与对照组的差异均有统计学意义（P<0.05）;肝硬化Child-Pugh各分级比较中,A、B、C级血小板参数逐渐降低,B、C组与A组比较差异有统计学意义,B、C级比较MPV、PLT、PCT的差异有统计学意义（P<0.05）,PDW无统计学意义（P>0.05）; A、B、C级凝血指标中TT、APTT、PT逐渐增大,FIB逐渐降低,B、C组与A组比较差异有统计学意义,B、C级比较APTT、FIB的差异无统计学意义（P>0.05）,PT、TT差异有统计学意义（P<0.05）。结论 相较于正常人群,肝硬化患者各项凝血指标及血小板参数均出现异常,同时肝硬化严重程度不同的各项指标均有差异,凝血指标及血小板参数能够反映肝硬化患者病情的严重程度,对肝硬化的诊治有重要意义。

关键词: 肝硬化, 血小板参数, 凝血指标

Abstract: Objective To study the application value of examining coagulation indicator and platelet indicators in research for hepatic cirrhosis,and to discuss the clinical significance,so as to provide theory evidence for the diagnosis and treatment of hepatic cirrhosis. Method 80 cases of patients with hepatic cirrhosis treated in our hospital since January 2014 to January 2015 and 80 cases of normal people were selected as the object of study. Patients with hepatic cirrhosis were set as observation group,while normal people were set as control group. Patients in observation group were divided into level A,level B and level C in accordance with hepatic cirrhosis Child-Pugh classification standard. People in groups mentioned above were detected for platelet indicators and coagulation indicator via hematology analyzer and coagulometer. Platelet indicators includes platelet distribution width （PDW）,platelet count （PLT）,mean platelet volume （MPV） and plateletcrit （PCT）,while coagulation indicator includes Fibrinogen （FIB）,prothrombin time （PT）,thrombin time （TT） and activated partial thromboplastin time （APTT）. Results There was a significant difference in Platelet PDW,PLT,MPV and PCT between observation group and control group,and a significant difference in coagulation indicator FIB,PT,TT and APTT between observation group and control group,having statistical significance （P<0.05）. In comparison among hepatic cirrhosis Child-Pugh classification,the platelet indicator gradually decreased from level A,level B to level C. There was a distinct difference between group B &C and group A,and there was a significant difference between level B and level C in MPV,PLT and PCT,having statistical significance （P<0.05）. PDW had no statistical significance （P>0.05）. As for coagulation indicator in level A,level B and level C,TT,APTT and PT gradually increased,while FIB gradually decreased. There was a significant difference between group B&C and group A,and there was no significant difference in APTT and FIB between level B and level C （P>0.05）. PT and TT differ distinctly,having statistical significance （P<0.05）.Conclusion Compared with normal people,various coagulation indicators and platelet indicators of patients with hepatic cirrhosis were abnormal,and indicators vary in accordance with the severity of hepatic cirrhosis. Coagulation indicator and platelet indicator can reflect the severity of hepatic cirrhosis of patients,significantly for the diagnosis and treatment of hepatic cirrhosis.

Key words: Hepatic cirrhosis, Platelet indicator, Coagulation indicator

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