• 中国科学论文统计源期刊
  • 中国科技核心期刊
  • 美国化学文摘(CA)来源期刊
  • 日本科学技术振兴机构数据库(JST)
临床输血与检验

临床输血与检验 ›› 2018, Vol. 20 ›› Issue (4): 434-436.DOI: 10.3969/j.issn.1671-2587.2018.04.029

• 临床检验 • 上一篇    下一篇

41例梅毒患者脑脊液检测结果分析*

陈莉,常文娇,戴媛媛,刘家琴,聂正超   

  1. 230001 合肥,中国科学技术大学附属第一医院（安徽省立医院）检验科
  • 收稿日期:2018-03-17 出版日期:2018-08-20 发布日期:2018-08-14
  • 作者简介:陈莉（1984–）,女,安徽太湖人,主管检验师,硕士研究生,主要从事临床检验研究,（Tel）0551-62283162(E-mail)53931066@qq.com。
  • 基金资助:
    *本课题受安徽省青年基金资助（No.1808085QH255）资助

Analysis of Cerebrospinal Fluid in Patients with SyphiIis

CHEN Li,CHANG Wen-jiao,DAI Yuan-yuan,et al   

  1. Department of Laboratory,the First Hostpital of University of Science and Tenchnology of China,Hefei 230001
  • Received:2018-03-17 Online:2018-08-20 Published:2018-08-14

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摘要： 目的 分析梅毒患者脑脊液的实验室检查结果，探讨脑脊液检查在神经梅毒诊断中的价值。方法 回顾性分析本院2015年11月~2016年10月收治的41例梅毒患者脑脊液的甲苯胺红不加热血清试验（TRUST）、梅毒螺旋体特异性抗体明胶凝集试验（TPPA），以及常规、生化和免疫球蛋白IgG检查的结果。结果 确诊神经梅毒13例，神经梅毒疑似4例，排除神经梅毒24例。41例梅毒患者脑脊液检查中， TRUST阳性9例；TPPA阳性17例；白细胞升高（>10×106/L）3例（3/13）；蛋白异常（>0.6 g/L）7例（7/13），IgG升高（>34 mg/L）11例（11/13）；葡萄糖和氯化物基本正常；神经梅毒组与非神经梅毒组比较，脑脊液检查相关指标的差异有统计学意义。结论 神经梅毒发病隐匿，症状无特异性，易造成误诊或漏诊，对疑似病例应尽早做脑脊液相关检查，可为神经梅毒的早期诊断和治疗提供重要依据。

关键词: 脑脊液, 神经梅毒, TRUST, TPPA, 免疫球蛋白IgG

Abstract: Objective To analyze the results of laboratory examination in cerebrospinal fluids of the patients with syphilis and explore the significance of laboratory detection for the diagnosis of neurosyphilis. Methods The data of cerebrospinal fluids (CSF) examinations of 41 inpatients were retrospectively analyzed for TRUST, TPPA, CSF, biochemical markers and IgG from 2015 to 2016. Results Thirteen cases of neurosyphilis were definitely diagnosed, 4 cases were suspected of neurosyphilis, and 24 were excluded. Positive TRUST of CSF were found in 9 cases and positive TPPA were noted in 17 cases. The number of CSF leukocytes increased (>10×106/L) in 3 cases (3/13) and the level of abnormal proteins elevated (>0.6g/L ) in 7 cases (7/13). Eleven cases（11/13） had increased level of IgG (>34mg/L). No significant changes of glucose and chloride were found compared with the non-neurosyphilis group. Conclusion Early neurosyphilis is asymptomatic and easy to be misdiagnosed. Early CSF examination is recommended for timely treatments of neurosyphilis in suspected cases.

Key words: Cerebrospinal fluid , Neurosyphilis , TRUST, TPPA, IgG antibody

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