血小板衰老机制研究进展*

doi:10.3969/j.issn.1671-2587.2024.05.022

临床输血与检验 ›› 2024, Vol. 26 ›› Issue (5): 709-714.DOI: 10.3969/j.issn.1671-2587.2024.05.022

血小板衰老机制研究进展^*

杨华月, 娄璨, 雷航, 蔡晓红

上海交通大学医学院附属瑞金医院临床输血科,上海 200025

收稿日期:2024-07-08 出版日期:2024-10-20 发布日期:2024-09-20
通讯作者: 蔡晓红,主要从事临床输血与患者血液管理、疑难血型与分子诊断、成分血保存与代谢研究,（E-mail）cxh8407@126.com。雷航,主要从事临床输血疑难血型检测及分子机制研究、血小板保存与代谢方面研究,（E-mail）leihang8914@163.com。
作者简介:杨华月,主要从事血型变异的分子机制、血小板保存与代谢研究,（E-mail）3261066534@qq.com。娄璨,主要从事红细胞血型与输血免疫方面研究,（E-mail）loucan971217@163.com。
基金资助:
*本课题受国家自然科学基金项目（No.82070194,82370229）资助

Research Progress on the Mechanism of Platelet Senescence

YANG Huayue, LOU Can, LEI Hang, CAI Xiaohong

Department of Clinical Blood Transfusion, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025

Received:2024-07-08 Online:2024-10-20 Published:2024-09-20

摘要/Abstract

摘要： 近年来,血小板衰老机制的研究日益受到关注。随着检测技术的进步,研究人员能够对健康个体外周血中的血小板进行年龄分层研究,揭示了血小板衰老过程中在转录组和蛋白质组层面的广泛改变。病理生理学研究进一步明确了血小板在多种疾病中的关键角色,这些疾病与血小板的年龄变化密切相关。然而,血小板的衰老特征及其在疾病发展中的确切作用仍需进一步阐明。因此,了解生理状态下衰老血小板的生理特征及其分子机制是研究的关键。本文综述了健康条件下血小板衰老的转录组学和蛋白质组学研究,以及血小板周转变化在相关疾病中的研究进展,以期为探讨血小板衰老与疾病发生发展的关系提供参考。

关键词: 血小板, 衰老, 清除机制, 转录组学, 蛋白组学, 功能

Abstract: In recent years, the mechanisms of platelet aging have garnered increasing attention. With advancements in detection technologies, researchers are now able to study the age stratification of platelets in the peripheral blood of healthy individuals, revealing extensive changes at both the transcriptomic and proteomic levels during the aging process. Pathophysiological studies have further elucidated the critical role of platelets in various diseases, closely associated with age-related changes in platelets. However, the specific characteristics of platelet aging and their precise role in disease development remain to be fully elucidated. Therefore, understanding the physiological characteristics and molecular mechanisms of aging platelets under normal conditions is crucial for research. This review summarizes the transcriptomic and proteomic studies on platelet aging in physiological conditions, as well as the changes in platelet turnover in related diseases, aiming to provide a reference for exploring the relationship between platelet aging and disease development.

Key words: Platelet, Ageing, Clearance mechanism, Transcriptomics, Proteomics, Function

中图分类号:

R457

杨华月, 娄璨, 雷航, 蔡晓红. 血小板衰老机制研究进展^*[J]. 临床输血与检验, 2024, 26(5): 709-714.

YANG Huayue, LOU Can, LEI Hang, CAI Xiaohong. Research Progress on the Mechanism of Platelet Senescence[J]. JOURNAL OF CLINICAL TRANSFUSION AND LABORATORY MEDICINE, 2024, 26(5): 709-714.

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血小板衰老机制研究进展^*

Research Progress on the Mechanism of Platelet Senescence

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