自体输血对血浆麻醉药物浓度影响的相关研究进展*

doi:10.3969/j.issn.1671-2587.2025.01.017

临床输血与检验 ›› 2025, Vol. 27 ›› Issue (1): 121-126.DOI: 10.3969/j.issn.1671-2587.2025.01.017

自体输血对血浆麻醉药物浓度影响的相关研究进展^*

王金伙, 郭建荣

海军军医大学附属公利医院麻醉与围术期医学部,上海 200135

收稿日期:2024-07-19 发布日期:2025-02-25
通讯作者: 郭建荣,主要从事围术期输血与血液保护方向的研究,（E-mail）jianrguo@126.com。
作者简介:王金伙,主要从事围术期输血与血液保护方向的研究,（E-mail）1242630733@qq.com。
基金资助:
*本课题受上海市浦东新区卫生系统重点学科群建设项目（No.PWZxq2022-05）资助

Advances in Research on the Impact of Autologous Blood Transfusion on Plasma Concentrations of Anesthetic Drugs

WANG Jinhuo, GUO Jianrong

Department of Anesthesiology and Perioperative Medicine, Shanghai Gongli Hospital, Naval MillitaryMedical University, Shanghai 200135

Received:2024-07-19 Published:2025-02-25

摘要/Abstract

摘要： 自体输血技术是一种解决临床用血供需矛盾和输血难题的有效方法,其类型包括稀释式、回收式和贮存式等,主要是将患者自身预先贮存的血液或失血后回收的血液在患者需要输血时进行回输。自体输血已广泛应用于临床,选择得当的自体输血技术可显著降低对异体血的需求,降低异体输血相关并发症,有效避免传染性疾病的传播。但在应用中其不可避免地引起机体一系列的病理生理变化,进而可能影响术中麻醉药物的作用,最终影响患者术后恢复质量。本文重点围绕近年来不同自体输血技术对麻醉药血浆浓度影响的相关研究进展做一综述。

关键词: 自体输血, 血药浓度, 麻醉药

Abstract: Autologous blood transfusion technology serves as an efficacious solution to the clinical dilemma of blood supply and demand, as well as the challenges associated with transfusion therapy. The techniques encompass various methods, including preoperative hemodilution, intraoperative salvage, and blood storage. The core principle involves the reinfusion of the patient's own blood, which may have been banked in advance or retrieved post-hemorrhage, when transfusion is necessitated. The application of autologous blood transfusion in clinical practice has been widespread, and these techniques can markedly reduce the reliance on allogeneic blood, which not only minimizes the risks of allogeneic transfusion-related complications but also effectively circumvents the transmission of infectious diseases. Nevertheless, the implementation of autologous blood transfusion inevitably induces a cascade of pathophysiological alterations within the body. These changes have the potential to influence the pharmacodynamic profile of anesthetic agents administered during surgery, thereby impacting the process of postoperative recovery. This review focuses on recent advancements in the impact of different autologous blood transfusion techniques on the plasma concentrations of anesthetic drugs.

Key words: Autologous blood transfusion, Blood drug concentration, Anesthetic drugs

中图分类号:

R457.1

王金伙, 郭建荣. 自体输血对血浆麻醉药物浓度影响的相关研究进展^*[J]. 临床输血与检验, 2025, 27(1): 121-126.

WANG Jinhuo, GUO Jianrong. Advances in Research on the Impact of Autologous Blood Transfusion on Plasma Concentrations of Anesthetic Drugs[J]. JOURNAL OF CLINICAL TRANSFUSION AND LABORATORY MEDICINE, 2025, 27(1): 121-126.

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自体输血对血浆麻醉药物浓度影响的相关研究进展^*

Advances in Research on the Impact of Autologous Blood Transfusion on Plasma Concentrations of Anesthetic Drugs

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