储存血小板非编码RNA差异表达谱的研究及在临床输血中的应用*

doi:10.3969/j.issn.1671-2587.2022.01.027

临床输血与检验 ›› 2022, Vol. 24 ›› Issue (1): 120-126.DOI: 10.3969/j.issn.1671-2587.2022.01.027

储存血小板非编码RNA差异表达谱的研究及在临床输血中的应用*

郭天虹, 周炜鑫, 黄远帅

646000 四川泸州,西南医科大学附属医院输血科

收稿日期:2021-10-08 发布日期:2022-01-27
通讯作者: 黄远帅,男,博士,硕士生导师,主要从事临床输血与免疫研究,（E-mail）hys@live.cn。
作者简介:郭天虹（1992-）,女,四川内江人,技师,硕士,主要从事临床输血研究,（E-mail）476204033@qq.com。
基金资助:
*本课题受四川省卫计委基金项目（No.17PJ519）资助

Received:2021-10-08 Published:2022-01-27

摘要/Abstract

摘要： 储存血小板作为临床输血不可或缺的重要组成,其保存期和血液质量仍受到多种因素的影响和限制。近十年的研究显示,血小板在储存过程中伴随非编码RNA（ncRNAs）表达的表化,它们参与血小板活化、线粒体损伤、凋亡等过程。因此,ncRNAs可能是储存血小板质量和活性的重要生物标志物。同时,血小板细胞外囊泡通过参与ncRNAs的转移在血小板输注中发挥重要作用,是介导血小板输注相关不良反应和导致受血者机体病理变化的重要载体。研究ncRNAs如何参与血小板mRNAs表达的调控是了解储存血小板活化与代谢损伤等分子机制的关键,这可能有助于提高体外储存血小板的质量,延长保质期,改善输血患者的预后,更好地实现精准输血。

关键词: 储存血小板, 血小板外泌体/囊泡, microRNAs, lncRNAs, circRNAs, ncRNAs

中图分类号:

R457

郭天虹, 周炜鑫, 黄远帅. 储存血小板非编码RNA差异表达谱的研究及在临床输血中的应用*[J]. 临床输血与检验, 2022, 24(1): 120-126.

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储存血小板非编码RNA差异表达谱的研究及在临床输血中的应用*

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