脂肪酸合酶在自身免疫性疾病中的作用机制研究进展*

doi:10.3969/j.issn.1671-2587.2025.04.019

临床输血与检验 ›› 2025, Vol. 27 ›› Issue (4): 557-563.DOI: 10.3969/j.issn.1671-2587.2025.04.019

脂肪酸合酶在自身免疫性疾病中的作用机制研究进展^*

赵贤贤¹, 孙茂允¹, 李丹丹², 王志成²

¹济宁市第一人民医院,山东济宁 272000;
²复旦大学附属华山医院,上海 200040

收稿日期:2025-05-28 发布日期:2025-08-22
通讯作者: 王志成,主要从事输血免疫学研究,（E-mail）wangzhicheng@fudan.edu.cn。
作者简介:赵贤贤,主要从事输血免疫学研究,（E-mail）zhaoxian65@163.com。
基金资助:
*本课题受国家自然科学基金项目（No. 82470234）,中国输血协会威高科研基金项目（No. CSBT-WG-2024-01）资助

Advances in the Mechanism of Fatty Acid Synthase in Autoimmune Diseases

ZHAO Xianxian¹, SUN Maoyun¹, LI Dandan², WANG Zhicheng²

¹Jining No.1 People's Hospital, Jining 272000;
²Huashan Hospital Affiliated to FudanUniversity, Shanghai 200040

Received:2025-05-28 Published:2025-08-22

摘要/Abstract

摘要： 脂肪酸合酶（fatty acid synthase, FASN）是催化脂肪酸从头合成的关键酶,其传统功能主要涉及能量储存和生物膜构建。近年研究表明,FASN通过调控细胞信号转导、调节炎症反应及影响免疫细胞功能,在自身免疫性疾病的发生发展中发挥重要作用。本文综述了FASN的结构、对免疫细胞功能的调节作用及其在自身免疫性疾病中的作用机制,并探讨了以FASN为靶点的潜在治疗策略,旨在为自身免疫性疾病的治疗提供新的思路。

关键词: 脂肪酸合酶, 免疫细胞功能, 自身免疫性疾病

Abstract: Fatty acid synthase (FASN) is a key enzyme that catalyzes the de novo synthesis of fatty acids, with its classical functions primarily associated with energy storage and biofilm construction. Accumulating evidence indicates that FASN contributes to the occurrence and development of autoimmune diseases through the regulation of cellular signal transduction, modulation of inflammatory responses, and influence on immune cell function. This review summarizes the structural characteristics of FASN, its regulatory roles in immune cell activity, its underlying mechanisms in autoimmune pathogenesis, and explores potential therapeutic strategies targeting FASN, with the aim of providing novel insights into the treatment of autoimmune disorders.

Key words: Fatty acid synthase, Immune cell function, Autoimmune diseases

中图分类号:

R593.2

赵贤贤, 孙茂允, 李丹丹, 王志成. 脂肪酸合酶在自身免疫性疾病中的作用机制研究进展^*[J]. 临床输血与检验, 2025, 27(4): 557-563.

ZHAO Xianxian, SUN Maoyun, LI Dandan, WANG Zhicheng. Advances in the Mechanism of Fatty Acid Synthase in Autoimmune Diseases[J]. JOURNAL OF CLINICAL TRANSFUSION AND LABORATORY MEDICINE, 2025, 27(4): 557-563.

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脂肪酸合酶在自身免疫性疾病中的作用机制研究进展^*

Advances in the Mechanism of Fatty Acid Synthase in Autoimmune Diseases

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