• 中国科学论文统计源期刊
  • 中国科技核心期刊
  • 美国化学文摘(CA)来源期刊
  • 日本科学技术振兴机构数据库(JST)

临床输血与检验 ›› 2017, Vol. 19 ›› Issue (4): 340-342.DOI: 10.3969/j.issn.1671-2587.2017.04.008

• 临床输血 • 上一篇    下一篇

孕妇ABO血型系统以外不规则抗体致新生儿溶血病10例*

王淑平, 陈慧芬, 李志强   

  1. 201204 上海同济大学附属第一妇婴保健院(王淑平,陈慧芬);
    上海市第六人民医院输血科(李志强)
  • 收稿日期:2017-03-01 出版日期:2017-08-20 发布日期:2017-08-09
  • 通讯作者: 李志强(1962-),男,主任医师,教授,硕士生导师,主要从事血液系统疾病诊治与临床输血不良反应研究,(Tel)021-24058722(E-mail)kcb039@126.com。
  • 作者简介:王淑平(1978-),女,副主任技师,硕士,主要从事血型血清学研究,(Tel) 021-20261096(E-mail)wangshuping@51mch.com。
  • 基金资助:
    *本课题受第四轮(2015-2017年)上海市公共卫生重点建设项目《输血医学》(No.15GWZK0501)资助

Case Reports of N-ABO-Hemolytic Disease in Newborns Caused by Maternal Irregular Antibodies

WANG Shu-ping, CHEN Hui-fen, LI Zhi-qiang   

  1. Shanghai First Maternity and Infant Hospital,Tongji University School of Medicine,Shanghai201204
  • Received:2017-03-01 Online:2017-08-20 Published:2017-08-09

摘要: 目的 通过回顾性分析10例ABO血型系统以外不规则抗体致新生儿溶血病孕妇情况,明确孕妇不规则抗体与ABO血型系统以外新生儿溶血症发生的相关性。方法 应用NEO全自动血型分析仪检测血型和不规则抗体,对抗筛阳性结果进一步做抗体鉴定。74例不规则抗体阳性孕妇分娩后,留取新生儿脐带血或抽取静脉血2~5 ml,用于新生儿溶血病相关血型血清学检测。结果 23 241例样本中检测到不规则抗体共74例。孕妇分娩后,存活胎儿中有10例发生ABO血型系统以外的新生儿溶血症(N-ABO-HDN)。其中2例为抗M引起,3例为抗D抗体引起,5例为抗E(含抗Ec)抗体引起。结论 为保障产妇以及新生儿的生命安全,有必要提前对孕产妇进行血型和不规则抗体测定。对多次妊娠史,尤其是习惯性流产的孕产妇,尽早进行血型不规则抗体检测,发现异常尽早干预,能有效降低不良妊娠发生率,降低患儿死亡率。

关键词: 不规则抗体, 孕妇, 新生儿溶血病

Abstract: Objective To report 10 cases of N-ABO-hemolytic disease in newborns (N-ABO-HDN) caused by maternal irregular antibodies through retrospective analysis. Methods The NEO was used to detect the irregular antibodies,and the positive samples were further identified. Cord or venous blood were collected from 74 pregnant women with irregular antibodies for hemolytic disease of newborns after delivery. Results Seventy four of 23 241 cases were found to present positive irregular antibodies. Among them,10 case of the survived infants were diagnosed as N-ABO-HDN. Two cases showed anti M-HDN; 3 cases,anti D -HDN; and 5 cases,anti E (anti Ec) -HDN. Conclusion Examination of irregular antibodies in pregnant women is quite usefull in ensuring the security of both mathers and foetuses. Early detection of irregular antibodies is crucial in multiparous pregnancies,especially in those with maternal habitual abortions.

Key words: Irregular antibody, Maternal, Hemolytic Disease of Newborn(HDN)

中图分类号: