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临床输血与检验

临床输血与检验 ›› 2018, Vol. 20 ›› Issue (3): 297-300.DOI: 10.3969/j.issn.1671-2587.2018.03.024

• 临床检验 • 上一篇    下一篇

血液透析联合血液灌注对维持性血液透析患者血清甲状旁腺激素的影响*

孙高中,高珺   

  1. 215101 江苏省苏州明基医院肾内科（孙高中）；徐州市中心医院肾内科（高珺）
  • 收稿日期:2018-01-17 出版日期:2018-06-20 发布日期:2018-06-22
  • 作者简介:孙高中（1979–），江苏灌南人，主治医师，学士，主要从事肾内科及血透工作，（Tel）13812762694（E-mail）zlnjjscx@163.com。
  • 基金资助:
    本课题受徐州中心医院博士（硕士）创新团队科技项目（No.xzs2013037）资助

Effect of Combined Hemodialysis with Blood Perfusion on Serum Parathyroid Hormone of Patients Undergoing Maintenance Hemodialysis

SUN Gao-zhong，GAO Jun.   

  1. Nephrology Department of BenQ Hospital，Suzhou 215101
  • Received:2018-01-17 Online:2018-06-20 Published:2018-06-22

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摘要： 目的 探析血液透析联合血液灌注应用于维持性血液透析患者治疗中对血清甲状旁腺激素的影响。方法 选取本院符合纳入标准的74例维持性血液透析患者，随机分为A、B两组，每组37例。A组采用单纯血液透析治疗，B组采用血液透析联合血液灌流治疗。观察两组治疗前后炎症因子水平、血清甲状旁腺激素水平、血清甲状旁腺激素清除率及临床症状改善情况和对比分析。结果 ①炎症因子水平：B组治疗后hs-CRP、TNF-α、IL-6低于A组，差异有统计学意义（P＜0.05）。②血清甲状旁腺激素：B组治疗后血清甲状旁腺激素指标低于A组，差异有统计学意义（P＜0.05）；B组治疗后血清甲状旁腺激素清除率高于A组，差异有统计学意义（P＜0.05）。③临床症状改善率：B组治疗后临床症状改善率优于A组，差异有统计学意义（P＜0.05）。结论 对于维持性血液透析患者定期进行血液透析联合血液灌流治疗，能够明显降低患者炎症因子和血清甲状旁腺激素水平，提高血清甲状旁腺激素清除率，改善临床症状。

关键词: 血液透析, 血液灌注, 维持性血液透析, 血清甲状旁腺激素

Abstract: Objective Analysis of the effect of United hemodialysis and hemoperfusion applied to hemodialysis patients in maintenance therapy on serum parathyroid hormone. Methods 74 cases in our hospital hemodialysis patients met the inclusion criteria were randomly divided into A，B group，37 cases in each group. A group using a simple blood dialysis treatment，group B hemoperfusion combined with hemodialysis. Observed levels of inflammatory cytokines before and after treatment，serum parathyroid hormone levels，serum parathyroid hormone clearance and improvement of clinical symptoms，and expand the comparative analysis. Results （1） levels of inflammatory factors：group B after treatment hs-CRP，TNF-α，IL-6 compared with group A，the difference was statistically significant （P<0.05）. （2） serum parathyroid hormones：parathyroid hormone index after treatment in group B compared with group A，the difference was statistically significant （P<0.05）; after treatment in group B serum parathyroid hormone clearance rate is higher than that in group A，the difference was statistically significant （P<0.05）. （3） the rate of clinical improvement：group B clinical symptoms improvement rate than A group，the difference was statistically significant （P<0.05）. Conclusion For patients undergoing maintenance hemodialysis regular hemodialysis combined with hemoperfusion therapy，can significantly reduce levels of inflammatory cytokines and serum parathyroid hormone levels in patients with increased serum parathyroid hormone clearance rate，improve clinical symptoms.

Key words: Hemodialysis , Blood perfusion , Hemodialysis, Serum parathyroid hormone

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