关键词: 红光照射, 维持性血液透析, 氧化应激, 血磷

Abstract: Objective To investigate the influences of external red light irradiationon on antioxidant capacity and blood phosphorus metabolism in maintenance hemodialysis （MHD） patients. Methods 86 MHD patients were selected from October 2015 to April 2018 in our hospital, who were randomly divided into test l group and control group, 43 cases in each group. The control group was given simple routine hemodialysis treatment, while the test group was exposed to external red light irradiation therapeutic apparatus during the hemodialysis. The general physiological conditions （body temperature, heart rate, blood pressure, respiration） and the contents of red blood cells and hemoglobin were observed before and after irradiation of the test group, and the changes of serum oxidative stress indexes [Superoxide dismutase （SOD）, malondialdehyde （MDA）, glutathione peroxidase （GSHPx）,advanced oxidation protein product （AOPP）] and serum phosphorus levels before the first dialysis and after 10 times of dialysis were compared between the 2 groups, and the adverse reactions during the irradiation of the test group were observed. Results There were no significant differences in body temperature, heart rate, mean arterial pressure, respiration, red blood cell count and hemoglobin content of the test group between before irradiation and after treatment （P>0.05）. The levels of serum SOD and GSH-Px of the control group after 10 times of hemodialysis were significantly lower than those before the first hemodialysis （P<0.05）, and the level of serum MDA of the control group after 10 times of hemodialysis was significantly higher than that before the first hemodialysis （P<0.05）, and there was no significant difference in serum AOPP level of the control group between after 10 times of hemodialysis and before the first hemodialysis （P>0.05）. The levels of serum SOD and GSH-Px of the test group after 10 times of hemodialysis were significantly higher than those before the first hemodialysis and of the control group （P<0.05）, and the levels of serum MDA and AOPP of the test group after 10 times of hemodialysis were significantly lower than those before the first hemodialysis and of the control group （P<0.05）. The levels of serum phosphorus in both groups were significantly lower after 10 times of hemodialysis than those before the first hemodialysis （P<0.05）, of which the test group after 10 times of hemodialysis was significantly lower than that of the control group （P<0.05）. No adverse reaction occurred in test group during the red light irradiation process. Conclusion External red light irradiation can significantly enhances the antioxidant capacity of MHD patients, reduces blood phosphorus level and does not produce adverse reactions, with high safety.

Key words: Red light irradiation, Maintenance hemodialysis, Oxidative stress, Blood phosphorus