血清AFP-L3%、CA125、CA199和IL-6变化与乙肝后肝硬化和癌变的相关性研究

doi:10.3969/j.issn.1671-2587.2019.05.026

临床输血与检验 ›› 2019, Vol. 21 ›› Issue (5): 535-538.DOI: 10.3969/j.issn.1671-2587.2019.05.026

血清AFP-L3%、CA125、CA199和IL-6变化与乙肝后肝硬化和癌变的相关性研究

黎增辉

410000 湖南长沙市第一医院

收稿日期:2018-04-19 出版日期:2019-10-20 发布日期:2019-10-29
作者简介:黎增辉（1985-）,女,湖南临湘人,主治医师,硕士,主要从事肝硬化研究,（Tel）15973187237。

Correlation between Changes of Serum AFP-L3%,CA125,CA199 and IL-6 Levels and Hepatitis B Induced Liver Cirrhosis and Cancer

LI Zeng-hui

First Hospital of Changsha,Hunan 410000

Received:2018-04-19 Online:2019-10-20 Published:2019-10-29

摘要/Abstract

摘要： 目的探讨AFP-L3%、CA125、CA199和IL-6水平变化与乙型肝炎致肝硬化和癌变的相关性。方法选取本院2016年12月~2017年12月收治的45例慢性乙型肝炎、41例乙肝后肝硬化和24例乙肝相关性肝癌患者为研究组,另选取30例健康者为对照组,检测所有研究对象的血清AFP-L3%、CA125、CA199和IL-6水平并比较。结果相比对照组,慢性乙型肝炎组和乙肝后肝硬化组及乙肝相关性肝癌组的AFP-L3%、CA125、CA199和IL-6水平均出现上升,差异有统计学意义（P均<0.05）。随着疾病的发展,慢性乙型肝炎组、乙肝后肝硬化组和乙肝相关性肝癌组的AFP-L3%和IL-6水平均逐渐上升。血清单项检测中灵敏度最高的是IL-6（91.67%）,特异性最高的是AFP-L3%（89.66%）;4项联合检测诊断的灵敏度、特异性及准确率都高于单项检测值。结论血清AFP-L3%、CA125、CA199和IL-6水平变化与乙肝致肝硬化和癌变之间存在相关性,且4个血清指标联合检测可以提高乙肝相关性肝癌的诊断效能,弥补单项检测的不足。

关键词: 甲胎蛋白异质体比值, 癌抗原125, 糖链抗原199, 白细胞介素-6, 肝癌

Abstract: Objective To investigate the correlation between the serum levels of AFP-L3%,CA125,CA199 and IL-6 and HBV induced liver cirrhosis and hepatocellular carcinoma.Methods Forty-five patients with chronic hepatitis B,41 patients with post-hepatitis B cirrhosis and 24 patients with hepatitis B-related liver cancer were selected as the study group,and 30 healthy persons were selected as the control group. Serum levels of AFP-L3%,CA125,CA199 and IL-6 were detected and compared.Results Compared with the control group,the levels of AFP-L3%,CA125,CA199 and IL-6 in chronic hepatitis B group,liver cirrhosis group and liver cancer group were significantly increased （P<0.05）. With the development of the disease,AFP-L3% and IL-6 levels in chronic hepatitis B group,liver cirrhosis group and liver cancer group increased gradually. IL-6 （91.67%） was the most sensitive and AFP-L3% （89.66%） was the most specific. The sensitivity,specificity and accuracy of the four combined tests were higher than those of single test.Conclusion sSerum AFP-L3%,CA125,CA199 and IL-6 levels were correlated with liver cirrhosis and canceration caused by hepatitis B,and the combined detection of four serum indicators could improve the diagnostic efficiency of liver cancer B and make up for the defect of single detection.

Key words: AFP-L3%, CA125, CA199, IL-6, Liver cancer

中图分类号:

R446.11 R735.7

黎增辉. 血清AFP-L3%、CA125、CA199和IL-6变化与乙肝后肝硬化和癌变的相关性研究[J]. 临床输血与检验, 2019, 21(5): 535-538.

LI Zeng-hui. Correlation between Changes of Serum AFP-L3%,CA125,CA199 and IL-6 Levels and Hepatitis B Induced Liver Cirrhosis and Cancer[J]. JOURNAL OF CLINICAL TRANSFUSION AND LABORATORY MEDICINE, 2019, 21(5): 535-538.

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血清AFP-L3%、CA125、CA199和IL-6变化与乙肝后肝硬化和癌变的相关性研究

Correlation between Changes of Serum AFP-L3%,CA125,CA199 and IL-6 Levels and Hepatitis B Induced Liver Cirrhosis and Cancer

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