• 中国科学论文统计源期刊
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临床输血与检验 ›› 2016, Vol. 18 ›› Issue (1): 32-35.DOI: 10.3969/j.issn.1671-2587.2016.01.011

• 临床检验研究 • 上一篇    下一篇

血清标记物联合检测对肝癌的临床诊断价值

叶芳,计海芬,罗锐,汪学龙   

  1. 230000 中科院合肥研究院肿瘤医院检验科(叶芳,计海芬),合肥市第一人民医院检验科(罗锐); 安徽医科大学病原生物学教研室(汪学龙)
  • 收稿日期:2015-07-28 出版日期:2016-02-20 发布日期:2016-10-10
  • 作者简介:(1980-),女,安徽东至人,主管技师,硕士,主要从事临床检验和血吸虫免疫诊断的研究,(Tel)13865997601(E-mail)764002645@qq.com。

The Clinical Value of Combined Detection of Serum Tumor Markers in Diagnosis of Liver Cancer

YE Fang, JI Hai-fen, LUO Rui, et al   

  1. Clinical Laboratory,Cancer Hospital,Chinese Academy of Sciences, Hefei 230032
  • Received:2015-07-28 Online:2016-02-20 Published:2016-10-10

摘要: 目的探讨血清标记物联合检测对肝癌患者的临床诊断价值。方法选取本院收治的56例原发性肝癌、32例肝病患者以及同期体检的34名健康者作为研究对象,检测血清中的癌胚抗原(CEA)、恶性肿瘤生长因子(TSGF)、谷氨酰转肽酶(GGT)、甲胎蛋白(AFP)以及岩藻糖苷酶(AFU)标记物。结果原发性肝癌患者的AFP、TSGF、AFU、GGT以及CEA等指标高于良性肝病和正常体检者(P<0.05);联合检测的敏感性和特异性均高于单一检测(P<0.05)。结论联合检测血清标记物能够有效提高肝癌的诊断敏感性。

关键词: 肿瘤标记物, 肝癌, 诊断, 检测

Abstract: ObjectiveTo explore the clinical value in combined detection of the serum tumor markers on patients with hepatocellular carcinoma. Methods56 cases primary liver cancer of the hospitalized patients, 32 cases of other liver diseases, and 34 healthy persons were collected. Carcinoembryonic antigen (CEA), serum malignant tumor growth factor (TSGF), glutamate based transpeptidase (GGT), alpha fetoprotein (AFP) and fucosidase (AFU) were determined. ResultsIndexes AFP, TSGF, AFU, GGT and CEA in patients with primary liver cancer were higher than those with benign liver diseases and normal control (P<0.05). The sensitivity and specificity of combined detection were higher than those of the single test (P <0.05). ConclusionThe combined detection of serum tumor markers of liver cancer can effectively improve the accuracy of diagnosis, and provide important basis for the differential diagnosis of hepatocellular carcinoma.

Key words: Serum, tumor, marker, Liver, cancer, Diagnosis, Detection

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