• 中国科学论文统计源期刊
  • 中国科技核心期刊
  • 美国化学文摘(CA)来源期刊
  • 日本科学技术振兴机构数据库(JST)
临床输血与检验

临床输血与检验 ›› 2019, Vol. 21 ›› Issue (6): 575-578.DOI: 10.3969/j.issn.1671-2587.2019.06.005

• 临床检验 • 上一篇    下一篇

IVF胚停患者绒毛染色体及相关免疫指标分析*

张娱, 许波, 郭楠, 周桂香, 李叶林, 孙晓科, 吴莉   

  1. 230001 中国科学技术大学附属第一医院（安徽省立医院）生殖中心（张娱,许波,郭楠,周桂香,孙晓科,吴莉）;
    安徽医科大学（李叶林）
  • 收稿日期:2019-06-01 出版日期:2019-12-20 发布日期:2019-12-25
  • 通讯作者: 吴莉,女,安徽合肥人,博士后,副主任医师,主要从事生殖免疫研究,（E-mail）wuli.0722@163.com。
  • 作者简介:张娱（1987-）,女,安徽黄山人,硕士,住院医师,主要从事生殖医学工作,（E-mail）zhangyu_mary@163.com。
  • 基金资助:
    *本课题受国家基金委自然科学基金青年项目（No.816013-53）资助

Analysis of Chorionic Chromosomes and Related Immune Indicators in Patients with IVF Embryo Abortion

ZHANG Yu, XU Bo, GUO Nan, et al   

  1. The First Affiliated Hospital of USTC,Division of Life Sciences and Medicine,University of Science and Technology of China,Hefei,Anhui 230001
  • Received:2019-06-01 Online:2019-12-20 Published:2019-12-25

PDF

1131

摘要： 目的 研究辅助生殖技术后胚胎停育患者绒毛染色体同年龄、胚停史及自身免疫性抗体之间的关系。方法 回顾性分析2016年2月~2018年8月进行体外受精-胚胎移植（in vitro fertilization and embyro transplantation,IVF-ET）助孕术后孕早期胚胎停育行绒毛染色体检查的患者113例。同时检测患者抗核抗体（anti-nuclear antibody,ANA）、抗心磷脂抗体（anti-cardiolipin antibody,ACA）抗甲状腺过氧化物酶抗体（anti-thyroperoxidase,ATA）、抗甲状腺球蛋白抗体（anti-thyroglobulin,ATG）。结果 ①113例患者染色体正常64例,染色体异常者49例;② 35岁以上患者染色体异常率显著高于35岁以下患者（67.57% VS 31.58%,P<0.000 1）;③既往有无胚停史、胚停次数与绒毛染色体异常之间并无显著联系;④染色体正常组中测出ACA、ANA、ATA/ATG阳性率虽高于染色体异常组,但差异不显著。结论 随着年龄增加,染色体异常比例显著增高;既往有无胚停史与染色体是否异常之间并无显著联系。

关键词: 绒毛染色体, 体外受精-胚胎移植, 抗心磷脂抗体, 抗核抗体, 抗甲状腺过氧化物酶抗体, 抗甲状腺球蛋白抗体

Abstract: Objective To investigate the relationships between missed abortion and age,autoimmune antibody,the history of spontaneous abortion among women after invitro fertilization-embryo transfer（IVF-ET）. Methods A retrospective analysis was made on 113 cases of chorionic chromosome examination in early abortion after IVF-ET from February 2016 to August 2018. Anti-nuclear antibody（ANA）,anti-cardiolipin antibody（ACA）,anti-thyroid peroxidase antibody（ATA） and anti-thyroglobulin antibody（ATG） were also detected. Results ①64 patients had normal chromosomes in 113 cases. Chromosome abnormalities were found in 49 cases. ②Chromosome abnormality rate of patients over 35 years old was significantly higher than that of patients under 35 years old（67.57% VS 31.58%,P<0.000 1）; ③There was no significant correlation between the history or times of early abortion and the chromosomal abnormalities. ④The positive rates of ACA,ANA and ATA/ATG in normal chromosome groups were higher than those in chromosomal abnormality groups,but without significant difference. Conclusion The rate of chromosome abnormalities increases with age. There is no significant relationship between the history of early abortion and the abnormalities of chorionic chromosomes after IVF-ET.

Key words: Chorionic chromosomes, IVF-ET, ACA, ANA, ATA, ATG

中图分类号: