Abstract: Objective To investigate the epidemiological features of volunteer blood donors infected with HIV in Wuxi,and to reduce the risk of blood-borne infections. Methods Data of the blood donors with HIV infection from 2011 to 2015 were collected,and the features of homosexual and non-homosexual individuals were analyzed in parallel. Results Fifty-five donors were confirmed to have HIV infection in the survey. Most HIV carriers were single males and had nonlocal residence，and gave their first donations personally or in group between the age of 20 to 40 years. Workers and farmers and those with high education dominated. Seven persons were found to have underling syphilis. In addition，the majority of the HIV infected homosexuals were local residents and workers when compared to the non-homosexuals who were farmers and nonlocal residents（P=0.042，P=0.031）. Conclusion HIV infection tends to spread from high-risk persons to general population. Measures must be taken based on the characteristic of the infection to ensure the blood safety.