Abstract: Objective To investigate the current status and characteristics of HIV infection among voluntary non-remunerated blood donors in Guangzhou from 2010 to 2015 and to provide evidence for new strategies which will ensure the adequacy and safety of blood recruitment.Methods A total of 1 553 378 blood specimens of voluntary non-remunerated blood donors were screened for HIV by ELISA and NAT. All the specimens which were positive in the two testing were sent to CDC for confirmation test. The epidemiological features of voluntary non-remunerated blood donors with HIV positive were collected and analyzed.Results 460 donors were confirmed with HIV positive among the 1 553 378 blood specimens,with a positive rate of 29.6/100 000. Not only the number of the infected donors but also the positive rate of infection was increasing year by year. The HIV positive rate of male （42.0/100 000） is much higher than that of female （5.2/100 000）. HIV positive rates among different age groups were statistically different. The positive rate in different age groups ranged from high to low was 26-35 years old group,18-25 years old group,36-45 years old group,and 46-60 years old group. A total of 103 cases of HIV infection combined with other items,accounting for 22.4%,of which syphilis,hepatitis C and hepatitis B dominated. The HIV positive rate of first-time donors （32.9/100 000） is higher than that of repeated donors （ 24.6/100 000）,and the HIV positive rate of repeated donors is increasing. The HIV positive rate of individual donors （49.0/100 000）is significantly higher than that of group donors （8.6/100 000）.The HIV positive rate of whole blood donors （31.2/100 000）is clearly higher than that of component blood donors （3.4/100 000）. Conclusions In Guangzhou,the rate of HIV infection is increasing year by year,and the lowering trend of HIV infection age is obviously shown. And male,individual,first-time and whole blood donors have a significantly higher infection rate. To further reduce the risk of HIV transmission through blood transfusion,targeted blood donation and recruitment strategies should be developed for different blood donors; meanwhile,screening for HIV and / or its co-infected items on-site may be effective.

Key words: Voluntary blood donors HIV infection, Repeated donors, Co-infection