Abstract: Objective Comparison of platelet quality between machine preparation of platelet and manual preparation.Method 400 ml of blood extracted from 60 donors. Platelet concentrates were obtained by Methods of Machine preparation and manual preparation. Platelet recovery,platelet count,platelet capacity,red blood cell residue were detected. Results The Buffer-coat-derived platelet recovery rate by Machine were higher than by manual separation preparation （P<0.05）. There is no difference of The account of Red blood cell residue by Machine and by manual（P>0.05）.CV of platelet capacity by mannual was higher than that of machine（P<0.05）.Conclusion Machine preparation of collected concentrated platelet has higher platelet recovery and capacity than manual preparation of platelets.

Key words: Buffy-coat-derived platelet, Platelet concentrates by hand, Platelet concentrates by machine Quality analysis