Abstract: Objective To investigate the relationship between platelet storage lesion and treatment efficacy of platelet transfusion. Method sThe platelet aggregation function and P-selectin were measured in 64 patients with hematologic disorders. The platelet recovery rate (PPR),platelet increase index (CCI) and hemostasis were measured for evaluation of transfusion efficacy and the correlation between platelet storage lesion and platelet recovery was analyzed. Results The effective CCI value of platelet transfusion was (16.0±5.5) in 40 patients,the CCI value of 24 cases was (3.4±1.0),the median of maximal platelet aggregation rate(Mean％±SD％),the minimum value (min%) - maximum value (max%) were 48.1±4.7(41.1~56.2),38.1±3.5(31.2~43.1),17.4±2.4(14.5~20.9),and 9.6±3.3(5.8~19.9) from 2d to 5d of validation. The contents of plasma soluble P-selectin (Mean±SD) were (11.4±5.8),(28.9±7.5),(55.5±8.4),and (89.2±5.6)ng/mL in the period of validation. A significant positive correlation was seen between platelet aggregation function and platelet transfusion efficacy (r=0.892,P<0.01),while a marked negative correlation between plasma soluble P-selectin concentration and platelet transfusion efficacy (r=–0.836,P<0.01). Conclusion Platelet injury during the period of platelet preservation may affect the incidence of platelet transfusion inefficiency. The transfusion efficacy can be improved by incorporating the functional criteria of apheresis platelets into clinical study.

Key words: Apheresis, platelets, Platelet, storage, lesion, Transfusion, efficacy