Abstract: Objective To investigate the clinical effect and safety of autologous blood donation before spinal surgery. Methods A restropective analysis was performed on 134 cases of benign spinal diseases in Guangzhou First People's Hospital. They were divided into autologous blood group（n=77）and allogeneic transfusion group（n=57）.The length of hospital stay, hemoglobin (Hb) changes and the transfusion related adverse reactions of two groups were recorded and compared. Results All the patients in autologous blood group had no related adverse reactions during preoperative blood donation and transfusion. Compared to allogeneic transfusion group, blood transfusion volume [（347.85±66.72）mL v.s. （478.88±194.23）mL,P<0.001）], the total length of hospital stay [（19.3±8.8）d v.s.（25.4±11.7）d, P=0.002）]and the length of postoperative hospital stay（10.77±5.41d v.s. 16.43±8.41d,P<0.001）were significantly reduced in autologous blood group. There were no significant differences in hemoglobin [（115.30±12.94）g/L v.s.（110.35±16.71）g/L,P=0.075] and hematocrit（0.34±0.03 v.s. 0.33±0.05,P=0.088）one day after operation between two groups. Conclusion Preoperative autologous donation is safe and economical in spinal surgery, which could effectively decrease the volume of allogeneic transfusion and the length of hospital stays.

Key words: Preoperative autologous blood donation, Spinal surgery, Efficacy, Safety