Abstract: Objective Analysis of the effect of United hemodialysis and hemoperfusion applied to hemodialysis patients in maintenance therapy on serum parathyroid hormone. Methods 74 cases in our hospital hemodialysis patients met the inclusion criteria were randomly divided into A，B group，37 cases in each group. A group using a simple blood dialysis treatment，group B hemoperfusion combined with hemodialysis. Observed levels of inflammatory cytokines before and after treatment，serum parathyroid hormone levels，serum parathyroid hormone clearance and improvement of clinical symptoms，and expand the comparative analysis. Results （1） levels of inflammatory factors：group B after treatment hs-CRP，TNF-α，IL-6 compared with group A，the difference was statistically significant （P<0.05）. （2） serum parathyroid hormones：parathyroid hormone index after treatment in group B compared with group A，the difference was statistically significant （P<0.05）; after treatment in group B serum parathyroid hormone clearance rate is higher than that in group A，the difference was statistically significant （P<0.05）. （3） the rate of clinical improvement：group B clinical symptoms improvement rate than A group，the difference was statistically significant （P<0.05）. Conclusion For patients undergoing maintenance hemodialysis regular hemodialysis combined with hemoperfusion therapy，can significantly reduce levels of inflammatory cytokines and serum parathyroid hormone levels in patients with increased serum parathyroid hormone clearance rate，improve clinical symptoms.

Key words: Hemodialysis , Blood perfusion , Hemodialysis, Serum parathyroid hormone