Abstract: Objective To provide scientific and safe blood transfusion measures for our hospital, we analyzed the adverse reactions of blood transfusion among clinical blood recipients and their related factors. Methods Through the clinical blood transfusion management system, we counted the total number of people who received blood transfusion treatment in our hospital from January 2021 to September 2022. At the same time, we collected the number and types of patients with adverse blood transfusion reactions during this period, and analyzed the relationship between adverse blood transfusion reactions and age, gender, blood transfusion history, blood components transfused, disease types, etc. Results We found that 92 377 people received blood transfusion treatment during this period, and 276 of that experienced adverse transfusion reactions. The total incidence of adverse reactions to blood transfusion was 0.30%, of which the incidence of adverse reactions to platelets was the highest (0.70%), followed by fresh frozen plasma and suspended red blood cells (0.50% and 0.31%). The incidence of non hemolytic febrile reaction of red blood cells, platelets and plasma was 0.11%, 0.05% and 0.004% respectively, and the allergic reaction was 0.06% (red blood cells), 0.64% (platelets) and 0.16% (plasma) respectively. The incidence of non hemolytic febrile reaction of suspended red blood cells (0.23%) was higher than that of leukocyte depleted suspended red blood cells (0.04%). but there was no difference in the incidence of allergic reaction between the two components (0.06% and 0.07%). The incidence of allergic reaction in fresh frozen plasma (0.50%) was higher than that in other plasma products; and the adverse reaction rate of platelet concentrate (0.65%) was higher than that of apheresis platelets (1.09%). The department with the highest incidence of adverse reactions of blood transfusion was the Department of Hematology, followed by the Department of Renal Transplantation. We found that there were statistically significant differences in the incidence of adverse reactions to blood transfusion among patients of different ages, with or without blood transfusion history, and with different blood components, but there was no statistically significant difference in the incidence of adverse reactions to blood transfusion among patients of different genders. Conclusion The occurrence of adverse reactions of blood transfusion is related to the blood components of transfusion and the patient's own factors. When applying for blood transfusion, clinicians should integrate multiple factors and select appropriate blood varieties to lower the likelihood of unfavorable blood transfusion reactions; At the same time, the hospital should ameliorate the reporting system of adverse transfusion reactions, strengthen the training of medical staff on transfusion related knowledge, and improve the knowledge of medical workers on reporting adverse transfusion reactions.

Key words: Clinical transfusion, Transfusion adverse reaction, Non-hemolytic febrile reactions, Allergic reactions