The Development Fibrinogen in the Treatment of Massive Traumatic Hemorrhage

doi:10.3969/j.issn.1671-2587.2024.02.018

JOURNAL OF CLINICAL TRANSFUSION AND LABORATORY MEDICINE ›› 2024, Vol. 26 ›› Issue (2): 274-281.DOI: 10.3969/j.issn.1671-2587.2024.02.018

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The Development Fibrinogen in the Treatment of Massive Traumatic Hemorrhage

SHANG Wei, WANG Deqing

Department of Transfusion Medicine, The First Medical Center of Chinese PLA General Hospital, Beijing 100853

Received:2024-01-25 Online:2024-04-20 Published:2024-04-23

Abstract

Abstract: Fibrinogen is a coagulation protein with the highest concentration in the blood circulation. During the treatment of massive traumatic hemorrhage, more and more evidence showed that fibrinogen played a key role not only as the main hemostatic component, but also as a regulator in inflammatory immunity and the anti-microbial infection. This article provides a brief overview of the multiple function of fibrinogen in the treatment of massive traumatic hemorrhage from the prospective of its influence on the early and late mortality, aiming to provide more theoretical supports to the early and sufficient fibrinogen replacement.

Key words: Fibrinogen, Platelet, Massive traumatic hemorrhage, Endotheliopathy of trauma, Sepsis

CLC Number:

R457

SHANG Wei, WANG Deqing. The Development Fibrinogen in the Treatment of Massive Traumatic Hemorrhage[J]. JOURNAL OF CLINICAL TRANSFUSION AND LABORATORY MEDICINE, 2024, 26(2): 274-281.

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The Development Fibrinogen in the Treatment of Massive Traumatic Hemorrhage

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