Influence Factors of Donation Related Vasovagal Reactions in Whole Blood Donors: A Systematic Review and Meta-analysis

doi:10.3969/j.issn.1671-2587.2025.03.017

JOURNAL OF CLINICAL TRANSFUSION AND LABORATORY MEDICINE ›› 2025, Vol. 27 ›› Issue (3): 384-392.DOI: 10.3969/j.issn.1671-2587.2025.03.017

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Influence Factors of Donation Related Vasovagal Reactions in Whole Blood Donors: A Systematic Review and Meta-analysis

WANG Jing^1,2, WU Kai¹, SUN Zhifang^2,3, WANG Mengxuan¹, GUO Rong¹, MA Chunying^4,5

¹Urumqi Blood Center, Urumqi 830000;
²School of Nursing of Xin Jiang Medical University, Urumqi 830011;
³Karamay Hospital of Xinjiang Uygur Autonomous Region, Karamay 834000;
⁴People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi 830001;
⁵Health Care Research Center for Xinjiang Regional population, Urumqi 830001

Received:2024-02-26 Published:2025-06-23

Abstract

Abstract: Objective To systematically analyze the risk factors of donation related vasovagal reaction (DRVR) in whole blood donors. Methods This study utilized databases such as PubMed and Web of Science to retrieve research data on the risk factors of DRVR in whole blood donors. Meta-analysis was done using RevMan5.4 software to process the data. Results A total of 24 relevant studies were in the analysis, involving 62 623 blood donors with DRVR. Meta-analysis revealed that first-time donors, female gender, age<25 years old, BMI<18.5, weight<55 kg, pulse rate > 90/min, estimated blood volume<3.5 L, fear emotion, recruitment blood donation and time after eating>4 h were significant risk factors for DRVR. Conclusion There are numerous risk factors for DRVR in blood donors. High risk population should be evaluated and screened in light of these factors, and timely interventions and nursing measures should be implemented to reduce the incidence of DRVR.

Key words: Blood donors, Donation related vasovagal reaction, Risk factors, Meta-analysis

CLC Number:

R457

WANG Jing, WU Kai, SUN Zhifang, WANG Mengxuan, GUO Rong, MA Chunying. Influence Factors of Donation Related Vasovagal Reactions in Whole Blood Donors: A Systematic Review and Meta-analysis[J]. JOURNAL OF CLINICAL TRANSFUSION AND LABORATORY MEDICINE, 2025, 27(3): 384-392.

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Influence Factors of Donation Related Vasovagal Reactions in Whole Blood Donors: A Systematic Review and Meta-analysis

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