• 中国科学论文统计源期刊
  • 中国科技核心期刊
  • 美国化学文摘(CA)来源期刊
  • 日本科学技术振兴机构数据库(JST)

JOURNAL OF CLINICAL TRANSFUSION AND LABORATORY MEDICINE ›› 2024, Vol. 26 ›› Issue (6): 805-811.DOI: 10.3969/j.issn.1671-2587.2024.06.016

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Meta Analysis of Incidence of Platelet Antibody in Pregnant Women in China

LI Xin1, YANG Junhong2   

  1. 1Department of Clinical Laboratory, the First Affiliated Hospital of Army Medical University, Chongqing 400038;
    2Chongqing Blood Center,Chongqing 400052
  • Received:2024-05-17 Online:2024-12-20 Published:2024-12-20

Abstract: Objective To evaluate the incidence of platelet antibodies in pregnant women and its influencing factors. Methods The databases PubMed, CNKI, EMbase, WanFang Data and VIP were searched for studies on platelet antibodies detection in pregnant women in China from the establishment of the database to March 2024. Meta-analysis was performed after literature screening and data extraction. Results Twenty-four studies totaling 41 079 pregnant women were finally included, of which 2 917 were positive for platelet antibody. The total platelet antibody positive rate in pregnant women was 8.05%. The total platelet antibody positive rate was 7.14% in the southern region, lower than 11.93% in the northern region (P<0.01). The positive rate of pregnant women with a history of pregnancy was 14.13%, higher than that of 3.15% in those without pregnancy history (P<0.01). The positive rates of platelet antibodies in pregnant women with 1, 2 and ≥3 or more pregnancies were 3.52%, 8.47% and 15.18, respectively, with statistically significant differences (P<0.01). The positive rates of platelet antibody among pregnant women with different modes of delivery were 10.10% and 8.49% for transvaginal and cesarean deliveries, respectively (P>0.05). The positive rates of platelet antibody in women with type A, B, O and AB were 8.86%, 7.25%, 6.38% and 5.55%, respectively (P>0.05). Conclusion The positive rate of platelet antibodies in Chinese pregnant women is correlated with region, pregnancy history and number of pregnancies, but not with delivery modes or ABO blood types.

Key words: Pregnant women, Platelet antibody, Meta-analysis

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