Abstract: Objective To investigate the predictive value of serum fibronectin （FN） in the risk of preeclampsia in obese pregnant women. Methods From January 2016 to May 2017,120 cases for health care during pregnancy pregnant women were selected in Hebei province people's Hospital,60 cases of normal pregnant women with normal blood pressure and no pre eclampsia,including pregnant women of normal weight （A group） and obese pregnant women （B group） each 30 cases; another 60 cases of pregnant women with preeclampsia,including pregnant women of normal weight （C group） and obese pregnant women （D group）each 30 cases,the serum FN levels were detected in pregnant women of four groups,and the outcome of pregnancy in patients with preeclampsia and pre eclampsia was compared. Results Compared with A group,the BMI,MAP,serum FN level of B group increased significantly（P<0.05）;Compared with C group,the BMI of D group increased significantly （P<0.05）,but MAP,serum level of FN was no statistical significance （P>0.05）;Compared with A and B group,the serum level of FN in C and D group significantly increased,and the D group was significantly higher than that of C group （P<0.05）;Compared with pre eclampsia,the cesarean section rate,neonatal Apgar score,fetal distress,premature delivery,intrauterine growth retardation were significantly reduced in no-preeclampsia pregnant women（P<0.05）,but there were no statistical significance in gestational age of delivery and stillbirth between above two groups （P>0.05）. Conclusion The detection of serum FN level has some predictive value for the risk of pre eclampsia in pregnant women with obesity,and worse pregnancy outcome of preeclampsia.

Key words: Serum fibronectin, Pregnant women/Obesity, Pre-eclampsia, Risk