Abstract: Objective To analyze the blood routine parameters and iron nutrition status of male regular plateletpheresis donors in the Tianjin area, aiming to provide a basis for developing tailored care measures for blood donors and safeguarding their health and safety. Methods Totally 920 male regular blood donors of apheresis platelets at the Tianjin Blood Center from October 1 to December 31, 2023 were randomly selected to undergo blood routine, serum iron (SI), and serum ferritin (SF) tests. The data were analyzed from four dimensions: age, body mass index (BMI), blood donation interval, and annual apheresis frequency. The prevalence of low SF was compared across groups , and binary Logistic regression analysis was used to evaluate the factors influencing low SF occurrence. Results Across age groups, the trends of red blood cell (RBC) count, hemoglobin (Hb) level, hematocrit (HCT), and platelet count (PLT) initially declined before rise (P<0.05). As BMI increased, the RBC, Hb, HCT, and SF levels showed an upward trend, There were statistically significant differences in Hb, mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC), PLT, SF, and SI among groups with different donation intervals (P<0.05). Donors with a donation interval of 31~60 days had higher SF and SI levels compared to the other two groups. As the number of apheresis platelet donations increased, Hb, HCT, mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC), SF, and SI decreased, while PLT increased without anemia symptoms. The prevalence of low SF among male regular plateletpheresis donors was 30.43%, with no statistically significant differences (P>0.05) between age or BMI groups. However, donors with a donation interval of ≤30 days had a significantly higher low SF occurrence (33.93%, P<0.05). and the incidence of low SF increased with the annual number of apheresis donations (P<0.05). Logistic regression analysis confirmed that the annual number of apheresis donations as a key predictor of low SF. Conclusion Male regular plateletpheresis donors exhibit a compromised iron nutritional status, albeit without overt anemia symptoms. Shortened donation interval and increased annual donation frequency ate associated with decreased SF concentrations, suggestive of reduced iron reserves. Blood collection and supply organizations should promptly monitor donor iron nutrition, enhance health management and iron supplementation strategies, and formulate individualized care plans to safeguard donor health and maintain blood supply adequacy.

Key words: Apheresis platelet, Regular blood donors, Iron nutrition, Serum ferritin, Serum iron