• 中国科学论文统计源期刊
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JOURNAL OF CLINICAL TRANSFUSION AND LABORATORY MEDICINE ›› 2025, Vol. 27 ›› Issue (5): 613-620.DOI: 10.3969/j.issn.1671-2587.2025.05.005

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Prevalence of CMV Infection Markers in Chinese Voluntary Blood Donors:a Meta-analysis

GUO Wei, ZHANG Ting, WANG Rui, LIU Li, FENG Limei, XIAO Yan, ZHANG Hongfei, YU Yang   

  1. Department of Transfusion Medicine, The First Medical Center of PLA General Hospital, Beijing 100853
  • Received:2025-09-01 Revised:2025-09-10 Online:2025-10-20 Published:2025-10-11

Abstract: Objective To analyze the prevalence of human cytomegalovirus (CMV) infection markers among voluntary blood donors in China and to provide a basis for evaluating the necessity of CMV screening and formulating relevant strategies. Methods A systematic search was conducted in eight databases including CNKI, Wanfang Medical, VIP, CBM, PubMed, Embase, Web of Science, and Medline from inception to March 2024. Literature meeting the inclusion criteria was selected, and meta-analysis was performed using StataMP 17.0 software. Results Thirty-two studies were included, with sample sizes of 30 388 for CMV-IgG, 27 273 for CMV-IgM, and 12 934 for CMV-DNA. The pooled prevalence rates of CMV-IgG, CMV-IgM, CMV-DNA, and CMV-(IgG+IgM) were 88% [95%CI (81%, 94%)], 3% [95%CI (2%, 5%)], 6% [95%CI (3%, 9%)], and 1% [95%CI (1%, 2%)], respectively. Subgroup analysis showed that in southern China, the pooled prevalence rates of CMV-IgG, CMV-IgM, and CMV-DNA were 91% [95%CI (84%, 96%)], 4% [95%CI (2%, 7%)], and 3% [95%CI (1%, 6%)], respectively; in northern China, they were 83% [95%CI (72%, 94%)], 2% [95%CI (1%, 3%)], and 4% [95%CI (1%, 10%)], respectively. The pooled prevalence rates of CMV-IgG and CMV-IgM detected by ELISA were 85% [95%CI (69%, 96%)] and 3% [95%CI (2%, 5%)], respectively, while those detected by other methods were 88% [95%CI (87%, 89%)] and 3% [95%CI (2%, 4%)], respectively. Conclusion The prevalence of CMV infection is high among voluntary blood donors in China, with notable regional variations. Strengthening CMV screening is essential to prevent TT-CMV.

Key words: Voluntary blood donation, Cytomegalovirus, Meta-analysis, Transfusion safety, Prevalence, IgM, IgG, DNA

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