• 中国科学论文统计源期刊
  • 中国科技核心期刊
  • 美国化学文摘(CA)来源期刊
  • 日本科学技术振兴机构数据库(JST)

JOURNAL OF CLINICAL TRANSFUSION AND LABORATORY MEDICINE ›› 2024, Vol. 26 ›› Issue (6): 835-842.DOI: 10.3969/j.issn.1671-2587.2024.06.020

Previous Articles     Next Articles

Advances in Non-invasive Cell-free Fetal DNA Blood Group Testing in Prenatal Diagnosis

REN Daoju1, LI Xiaowei2, LI Cuiying1,2   

  1. 1Air Force Clinical College; the Fifth School of Clinical Medicine, Anhui Medical University, Hefei,232001;
    2Department of Blood Transfusion, Air Force Medical Center, Air Force Medical University, Beijing, 100142
  • Received:2024-06-18 Online:2024-12-20 Published:2024-12-20

Abstract: Cell-free fetal DNA (cff-DNA) exists in the peripheral blood of pregnant women during gestation, and it carries DNA fragments with relevant genetic information of the fetus, which can be screened for fetal chromosomal and gene-related diseases. It is now widely used in non-invasive prenatal testing (NIPT) because of its low operational risk and lack of side effects. Non-invasive cff-DNA blood group testing uses molecular technology to detect the genes associated with cff-DNA blood grouping, resulting in a fetal blood group. The test can be used to detect the consistency of fetal and maternal blood groups during pregnancy and to determine the risk of hemolytic disease of the fetus and newborn (HDFN) due to blood group incompatibility.

Key words: Cell free fetal DNA, Fetal blood type, Non-invasive prenatal testing

CLC Number: