• 中国科学论文统计源期刊
  • 中国科技核心期刊
  • 美国化学文摘(CA)来源期刊
  • 日本科学技术振兴机构数据库(JST)

JOURNAL OF CLINICAL TRANSFUSION AND LABORATORY MEDICINE ›› 2024, Vol. 26 ›› Issue (6): 818-824.DOI: 10.3969/j.issn.1671-2587.2024.06.018

Previous Articles     Next Articles

Research Progress of mTOR Pathway in Regulating Self-renewal and Differentiation of Hematopoietic Stem Cells

WANG Jiaqi1, XIAO Jun2, LI Cuiying1,2   

  1. 1Graduate School of Hebei North University, Zhangjiakou, Hebei Province 075000;
    2Department of Blood Transfusion, Air Force Medical Center, Beijing 100142
  • Received:2024-07-01 Online:2024-12-20 Published:2024-12-20

Abstract: The mammalian target of rapamycin (mTOR) is a serine/threonine protein kinase that plays an important role in regulating cell growth, proliferation.The mTOR complex regulates cell growth, proliferation, protein metabolism by phosphorylating and activating downstream substrates such as S6K1, 4E-BP, etc. The mTOR signalling pathway similarly plays an important role in the haematopoietic system, integrating multiple signals to regulate the three processes of haematopoietic stem cell quiescence, self-renewal and multidirectional differentiation.This article systematically describes how relevant signalling molecules and proteins affect the mTOR signalling pathway and further influence haematopoietic stem cell function.

Key words: Haematopoietic stem cells, mTOR signalling pathway, Haematopoietic differentiation, Self-renewal, Malignant haemopoiesis

CLC Number: