• 中国科学论文统计源期刊
  • 中国科技核心期刊
  • 美国化学文摘(CA)来源期刊
  • 日本科学技术振兴机构数据库(JST)

JOURNAL OF CLINICAL TRANSFUSION AND LABORATORY MEDICINE ›› 2024, Vol. 26 ›› Issue (6): 755-761.DOI: 10.3969/j.issn.1671-2587.2024.06.007

Previous Articles     Next Articles

Retrospective Analysis of the Efficacy of Postoperative Plasma Transfusion in Patients with Primary Liver Cancer Undergoing Liver Resection

CHE Yang, LIU Zheng, ZHOU Xiaoyu   

  1. Blood Transfusion Department, The First Affiliated Hospital with Nanjing Medical University, Nanjing 210029
  • Received:2024-05-27 Online:2024-12-20 Published:2024-12-20

Abstract: Objective To compare the efficacy of fresh frozen plasma infusion and virus inactivated frozen plasma infusion on the recovery of liver function and coagulation function in patients with primary liver cancer after hepatectomy. Methods A retrospective analysis was conducted on 394 inpatients who underwent partial hepatectomy for primary liver cancer in our hospital from January 1, 2020 to December 31, 2023. Based on the types of plasma transfused, the patients were categorized into two groups: the fresh frozen plasma group (n=128) and the virus inactivated frozen plasma group (n=266). Baseline data of the two groups were balanced by propensity score matching (PSM), and the preoperative data of the matched patients were analyzed. Liver function indicators such as alanine aminotransferase (ALT), aspartate aminotransferase (AST), cholinesterase (CHE), total bilirubin (TBIL), plasma total protein (TP), and albumin (ALB)after surgery and after plasma infusion, prothrombin time (PT), activated partial thromboplastin time (APTT), and prognosis (length of hospital stay, discharge assessment) were utilized to evaluate the efficacy of plasma infusion. Measurement data following a normal distribution were presented as the mean±standard deviation (), a T-test was employed for inter-group comparison, M(Q1, Q3) was adopted for inter-group comparison, U test was utilized for inter-group comparison, and a χ2 test was applied for inter-group comparison of count data. Results A total of 88 pairs of patients were included in the statistics after PSM, including fresh frozen plasma group (n=88) and virus inactivated frozen plasma group (n=88). Compared with the preoperative results, both groups of patients showed significant impairment in liver function and coagulation function after surgery; Plasma infusion can improve patients' liver function indicators and coagulation function; There was no significant difference in the indicators of ALT, AST, CHE, and TBIL between the fresh frozen plasma group and the virus inactivated frozen plasma group after transfusion; Through the comparison of the difference between before and after transfusion, we found that the difference in TP 5.75 (2.96, 8.15) and ALB 5.01 (3.20, 9.20) in the fresh frozen plasma group was greater than the difference in TP 1.20 (0.75, 3.12) and ALB 3.35 (0.50, 5.98) in the virus inactivated frozen plasma group (P<0.05); After infusion of fresh frozen plasma, the APTT and PT extension time were significantly shortened. The PT difference of 3.60 (2.40, 10.10) and APTT difference of 12.00 (4.10, 18.67) in the fresh frozen plasma group before and after plasma transfusion were greater than the PT difference of 1.10 (0.10, 3.30) and APTT difference of 1.70 (0.20, 6.38) in the virus inactivated frozen plasma group before and after plasma transfusion (P<0.05); Compared with the average hospitalization time of the virus inactivated frozen plasma group, the average hospitalization time of the fresh frozen plasma group was longer (26.07±1.92) days (P<0.05), but there was no statistical significance between the two groups in terms of discharge evaluation (P=0.839). Conclusion In patients with primary liver cancer who have undergone hepatectomy, the administration of fresh frozen plasma and virus inactivated frozen plasma can significantly promote the recovery of liver function; The infusion of fresh frozen plasma has no significant advantage in improving patient prognosis, but for patients with postoperative coagulopathy, the infusion of fresh frozen plasma can better improve their coagulation function and increase their protein levels.

Key words: Primary liver cancer, Fresh frozen plasma, Virus inactivated frozen plasma, Liver function, Blood coagulation function

CLC Number: