Abstract: Objective To investigate the concentration and its significance of interleukin -32 （IL-32） in sera of patients with asthma. Methods One hundred and sixty five cases of asthma were selected,including 65 cases of acute attack,42 cases of chronic asthma and 58 stable phases and 50 healthy controls. Enzyme linked immunosorbent assay was used to detect serum IL-32. The respiratory function,the number of EOS,ECP level,and ACT score were measured and the correlation between IL-32 and the serum indicators was analyzed. Results IL-32 concentrations were found to be 53.87+20.07 ng/L,43.48+7.17 ng/L,29.55+6.26 ng/L,and 13.68+4.16 ng/L in acute,chronic and stable asthma,and healthy control,respectively （P<0.05）. FEV1,FEV1/FVC and PEF increased while EOS and ECP decreased with remission of the disease. ACT score became high with amelioration. The concentration of IL32 in sera was negatively correlated with FEV1,FEV1/FVC and ACT,but positively correlated with EOS and ECP （P<0.05）. No correlation of IL32 level in the sera was noted with PEF. Conclusion IL-32 is closely related to the occurrence and advance of asthma. Monitoring concentration of IL-32 in the sera of patients may help for the diagnosis,treatment and prognosis of asthma.

Key words: Interleukin-32, Asthma, Prognosis